CALIBER Systemic sclerosis phenotype

person Phenotype Systemic sclerosis
person Type Disease or syndrome
person Data sources Primary care (CPRD), hospital admission data (HES)
person Clinical Terminologies Read, ICD-9, ICD-10
person Valid event date range 01/01/1999 - 01/07/2016
person Sex Female/Male
person Agreed 23.11.2012 (Revision 2)
person Authors Mar Pujades-Rodriguez , Bram Duyx, Sara L. Thomas, Dimitris Stogiannis, Anisur Rahman, Liam Smeeth, Harry Hemingway

Primary Care (incident and prevalent)

In the Clinical Practice Research Datalink (CPRD, primary care data) we ascertained cases by searching for Read terms related to:

Diagnoses

Read codeRead termCALIBER category
N001100 CREST syndrome Systemic sclerosis
N001.12 Systemic sclerosis Systemic sclerosis
N001000 Progressive systemic sclerosis Systemic sclerosis
Nyu4500 [X]Other forms of systemic sclerosis Systemic sclerosis
H572.00 Lung disease with systemic sclerosis Systemic sclerosis
Diagnoses (prevalent)

Read codeRead termCALIBER category
Disease-modifying antirheumatic drugs (DMARD)

Product codeMedication
3984 cyclophosphamide tablets 10mg
3985 cyclophosphamide tablets 50mg
10729 ENDOXANA tablets 50mg [BAXTER ONC]
16105 cyclophosphamide injection 500mg
26066 cyclophosphamide injection 200mg
26322 cyclophosphamide injection 100mg
29840 cyclophosphamide injection 1000mg
31193 ENDOXANA tablets 10mg [BAXTER ONC]
34728 CYCLOPHOSPHAMIDE tablets 50mg [PHARMACIA]

Read terms are hierarhically organized in top-level chapters i.e. chapter G....00 is related to Circulatory System Diseases and sub-headings i.e. heading G2...00 is related to Hypertensive Heart Disease while G3...00 is related to Ischaemic Heart Disease.

Secondary Care (incident and prevalent)

In Hospital Episode Statistics (HES, hospital admission data) we used ICD-10 terms (see below) for diagnosis when marked as the primary diagnosis i.e. the main condition treated or investigated during the relevant episode of healthcare. We used the date of admission to hospital as the date of the event. We additionally searched for OPCS-4 terms indicating releted procedures.

Diagnoses

ICD-10 codeICD-10 termCALIBER category
M340 Progressive systemic sclerosis Systemic sclerosis
M341 CR(E)ST syndrome Systemic sclerosis
M342 Systemic sclerosis induced by drugs & chemicals Systemic sclerosis
M348 Other forms of systemic sclerosis Systemic sclerosis
M349 Systemic sclerosis, unspecified Systemic sclerosis
Not applicable.
CALIBER Atrial Fibrillation Phenotype flowchart
Flow chart diagram illustrating the CALIBER phenotype algorithm for atrial fibrillation
Pujades-Rodriguez, Mar, Bram Duyx, Sara L. Thomas, Dimitris Stogiannis, Anisur Rahman, Liam Smeeth, and Harry Hemingway. "Rheumatoid arthritis and incidence of twelve initial presentations of cardiovascular disease: a population record-linkage cohort study in England." PLoS One 11, no. 3 (2016): e0151245.