CALIBER Primary biliary cirrhosis phenotype

person Phenotype Primary biliary cirrhosis
person Type Disease or syndrome
person Data sources Primary care (CPRD), hospital admission data (HES)
person Clinical Terminologies Read, ICD-9, ICD-10
person Valid event date range 01/01/1999 - 01/07/2016
person Sex Female/Male
person Agreed 23.11.2012 (Revision 2)
person Authors Mar Pujades-Rodriguez , Bram Duyx, Sara L. Thomas, Dimitris Stogiannis, Anisur Rahman, Liam Smeeth, Harry Hemingway

Primary Care (incident and prevalent)

In the Clinical Practice Research Datalink (CPRD, primary care data) we ascertained cases by searching for Read terms related to:

Diagnoses

Read codeRead termCALIBER category
J616000 Primary biliary cirrhosis Primary biliary cirrhosis
J616.00 Biliary cirrhosis Primary biliary cirrhosis
J661700 Primary sclerosing cholangitis Primary biliary cirrhosis
J616z00 Biliary cirrhosis NOS Primary biliary cirrhosis
Disease-modifying antirheumatic drugs (DMARD)

Product codeMedication
2307 URSODEOXYCHOLIC ACID 250 MG CAP
5637 ursodeoxycholic acid capsules 250mg
7766 DESTOLIT tablets 150mg [NORGINE]
8425 URSOFALK capsules 250mg [DR FALK]
8907 CHOLESTYRAMINE 325 MG CAP
9013 ursodeoxycholic acid tablets 150mg
9847 ursodeoxycholic acid tablets 250mg
11833 ursodeoxycholic acid tablets 300mg
12231 CHOLESTYRAMINE POW
13102 ursodeoxycholic acid sugar-free suspension 250mg/5ml
20118 URDOX film coated tablets 300mg [WOCKHARDT]
20736 CHOLESTYRAMINE SACHETS
20908 URSOGAL capsules 250mg [GALEN]
22494 COMBIDOL tablets 125mg + 125mg [CP PHARM]
23350 chenodeoxycholic acid and ursodeoxycholic acid tablets 125mg + 125mg
26911 URSOFALK suspension 250mg/5ml [DR FALK]
29176 URSOGAL tablets 150mg [GALEN]
33339 URSODEOXYCHOLIC ACID tablets 250mg [HILLCROSS]
34446 URSODEOXYCHOLIC ACID capsules 250mg [APS]
34790 URSODEOXYCHOLIC ACID tablets 150mg [HILLCROSS]
34935 URSODEOXYCHOLIC ACID tablets 300mg [CP PHARM]

Read terms are hierarhically organized in top-level chapters i.e. chapter G....00 is related to Circulatory System Diseases and sub-headings i.e. heading G2...00 is related to Hypertensive Heart Disease while G3...00 is related to Ischaemic Heart Disease.

Secondary Care (incident and prevalent)

In Hospital Episode Statistics (HES, hospital admission data) we used ICD-10 terms (see below) for diagnosis when marked as the primary diagnosis i.e. the main condition treated or investigated during the relevant episode of healthcare. We used the date of admission to hospital as the date of the event. We additionally searched for OPCS-4 terms indicating releted procedures.

Diagnoses

ICD-10 codeICD-10 termCALIBER category
K743 Primary biliary cirrhosis Primary biliary cirrhosis
Not applicable.

Combining evidence across sources to define and date phenotypes

CALIBER Atrial Fibrillation Phenotype flowchart
Flow chart diagram illustrating the CALIBER phenotype algorithm for atrial fibrillation
Pujades-Rodriguez, Mar, Bram Duyx, Sara L. Thomas, Dimitris Stogiannis, Anisur Rahman, Liam Smeeth, and Harry Hemingway. "Rheumatoid arthritis and incidence of twelve initial presentations of cardiovascular disease: a population record-linkage cohort study in England." PLoS One 11, no. 3 (2016): e0151245.