CALIBER Polymyalgia diagnosis phenotype

person Phenotype Polymyalgia diagnosis
person Type Disease or syndrome
person Data sources Primary care (CPRD), hospital admission data (HES)
person Clinical Terminologies Read, ICD-9, ICD-10
person Valid event date range 01/01/1999 - 01/07/2016
person Sex Female/Male
person Agreed 23.11.2012 (Revision 2)
person Authors Mar Pujades-Rodriguez , Bram Duyx, Sara L. Thomas, Dimitris Stogiannis, Anisur Rahman, Liam Smeeth, Harry Hemingway

Primary Care (incident and prevalent)

In the Clinical Practice Research Datalink (CPRD, primary care data) we ascertained cases by searching for Read terms related to:

Diagnoses

Read codeRead termCALIBER category
N20..00 Polymyalgia rheumatica Polymyalgia
N20..11 Polymyalgia Polymyalgia
N200.00 Giant cell arteritis with polymyalgia rheumatica Polymyalgia
Disease-modifying antirheumatic drugs (DMARD)

Product codeMedication
270 azathioprine injection 50mg/vial
451 azathioprine tablets 25mg
571 azathioprine tablets 50mg
671 IMURAN tablets 25mg [WELLCOME]
770 azathioprine capsules
823 methotrexate tablets 2.5mg
877 methotrexate tablets 10mg
1899 IMURAN tablets 50mg [WELLCOME]
3918 AZATHIOPRINE 10 MG TAB
7336 methotrexate injection 12.5mg/0.5ml
7337 methotrexate injection 10mg/0.4ml
8327 methotrexate injection 50mg/3ml
8583 methotrexate injection 25mg/ml
8776 AZATHIOPRINE 100 MG TAB
9528 methotrexate injection 5mg/2ml
12339 AZAMUNE tablets 50mg [PENN]
12816 methotrexate injection 100mg/ml
13320 azathioprine tablets 10mg
13428 MAXTREX tablets 2.5mg [PHARMACIA]
14347 methotrexate injection 20mg/0.8ml
14348 METOJECT injection 20mg/2ml [MEDAC UK]
14395 IMURAN injection 50mg/vial [WELLCOME]
14748 methotrexate sodium injection 25mg/ml
15556 AZATHIOPRINE 125 MG TAB
16519 methotrexate injection 25mg/1ml
16540 methotrexate injection 15mg/0.6ml
16570 methotrexate injection 7.5mg/0.3ml
17035 methotrexate suspension 2.5mg/5ml
17206 AZATHIOPRINE 50 MG SUS
17672 methotrexate injection 22.5mg/0.9ml
18424 methotrexate sodium tablets 2.5mg
18890 methotrexate injection 17.5mg/0.7ml
19072 OPRISINE tablets 50mg [OPUS]
20951 METHOTREXATE tablets 2.5mg [GOLDSHIELD]
21753 MAXTREX tablets 10mg [PHARMACIA]
21889 METHOTREXATE 25MG/1ML
21899 IMMUNOPRIN tablets 50mg [ASHBOURNE]
22982 azathioprine oral solution 50mg/5ml
24634 methotrexate injection 25mg/2.5ml
24783 methotrexate injection 50mg/2ml
26064 methotrexate injection 20mg/2ml
26261 BERKAPRINE tablets 50mg [RORER]
27342 MAXTREX injection 2.5mg/ml [PHARMACIA]
27400 METOJECT injection 15mg/1.5ml [MEDAC UK]
27404 methotrexate injection 15mg/1.5ml
27579 METHOTREXATE
27642 methotrexate injection 27.5mg/1.1ml
28041 methotrexate oral suspension 12.5mg/5ml
29069 methotrexate sterile powder 500mg/vial
29340 AZATHIOPRINE tablets 50mg [IVAX]
30495 IMURAN tablets 10mg [WELLCOME]
30703 methotrexate injection 30mg/1.2ml
30780 METHOTREXATE tablets 2.5mg [PHARMACIA]
30932 methotrexate injection 5mg/0.2ml
31215 AZATHIOPRINE tablets 50mg [KENT]
32101 AZATHIOPRINE tablets 25mg [HILLCROSS]
32111 METHOTREXATE tablets 2.5mg [MAYNE]
32229 methotrexate injection 500mg/20ml
32865 methotrexate injection 10mg/1ml
33601 METOJECT injection 25mg/2.5ml [MEDAC UK]
34258 METHOTREXATE injection 20mg/0.8ml [CENT HOME]
34451 AZATHIOPRINE tablets 50mg [GEN (UK)]
34687 AZATHIOPRINE tablets 50mg [HILLCROSS]
34816 AZATHIOPRINE tablets 25mg [GEN (UK)]
34929 METHOTREXATE tablets 10mg [MAYNE]
35402 methotrexate injection 7.5mg/0.75ml
35518 azathioprine oral suspension 50mg/5ml
35752 methotrexate oral suspension 7.5mg/5ml
35865 METOJECT injection 7.5mg/0.75ml [MEDAC UK]
36167 methotrexate injection 1000mg/10ml
36792 azathioprine oral solution 50mg/ml
36800 methotrexate oral solution 10mg/5ml
36849 methotrexate oral suspension 10mg/5ml
37117 METOJECT injection 10mg/1ml [MEDAC UK]
39115 azathioprine capsules 10mg
40273 methotrexate injection 20mg/0.4ml
40280 METOJECT injection 7.5mg/0.15ml [MEDAC UK]
40281 methotrexate injection 15mg/0.3ml
40284 METOJECT injection 15mg/0.3ml [MEDAC UK]
40292 METOJECT injection 20mg/0.4ml [MEDAC UK]
40293 METOJECT injection 25mg/0.5ml [MEDAC UK]
40301 methotrexate injection 7.5mg/0.15ml
40328 methotrexate injection 25mg/0.5ml
40356 METOJECT injection 10mg/0.2ml [MEDAC UK]
40371 methotrexate injection 10mg/0.2ml
41086 methotrexate injection 5000mg/50ml
41104 METHOTREXATE tablets 2.5mg [CP PHARM]
41585 METHOTREXATE SODIUM tablets 2.5mg [WYETH PHAR]
41620 AZATHIOPRINE tablets 50mg [TEVA]
41670 AZATHIOPRINE tablets 50mg [CP PHARM]

Read terms are hierarhically organized in top-level chapters i.e. chapter G....00 is related to Circulatory System Diseases and sub-headings i.e. heading G2...00 is related to Hypertensive Heart Disease while G3...00 is related to Ischaemic Heart Disease.

Secondary Care (incident and prevalent)

In Hospital Episode Statistics (HES, hospital admission data) we used ICD-10 terms (see below) for diagnosis when marked as the primary diagnosis i.e. the main condition treated or investigated during the relevant episode of healthcare. We used the date of admission to hospital as the date of the event. We additionally searched for OPCS-4 terms indicating releted procedures.

Diagnoses

ICD-10 codeICD-10 termCALIBER category
M353 Polmyalgia rheumatica Polymyalgia
M315 Giant cell arteritis with polymyalgia rheumatica Polymyalgia
Not applicable.
Pujades-Rodriguez M et al. Associations between polymyalgia rheumatica and giant cell arteritis and 12 cardiovascular diseases. Heart. 2016 Mar;102(5):383-9. doi: 10.1136/heartjnl-2015-308514. Epub 2016 Jan 19. PMID: 26786818
Pujades-Rodriguez M et al. Associations between polymyalgia rheumatica and giant cell arteritis and 12 cardiovascular diseases. Heart. 2016 Mar;102(5):383-9. doi: 10.1136/heartjnl-2015-308514. Epub 2016 Jan 19. PMID: 26786818
Pujades-Rodriguez M et al. Associations between polymyalgia rheumatica and giant cell arteritis and 12 cardiovascular diseases. Heart. 2016 Mar;102(5):383-9. doi: 10.1136/heartjnl-2015-308514. Epub 2016 Jan 19. PMID: 26786818