CALIBER Peripheral arterial disease phenotype

person Phenotype Peripheral arterial disease
person Type Disease or syndrome
person Data sources Primary care (CPRD), hospital admission data (HES), mortality data (ONS)
person Clinical Terminologies Read, ICD-10, ICD-9, OPCS-4
person Valid event date range 01/01/1999 - 01/07/2016
person Sex Female/Male
person Agreed 23.11.2012 (Revision 2)
person Authors Julie George, Emily Herrett, Liam Smeeth, Harry Hemingway, Anoop Shah, Spiros Denaxas

Primary Care (incident)

In the Clinical Practice Research Datalink (CPRD, primary care data) we ascertained peripheral arterial disease (PAD) cases by searching for Read and OPCS 4 terms related to peripheral vascular disease diagnosis OR leg or aortic embolism or thrombosis diagnosis OR PAD disease procedures (excluding repair of abdominal aortic aneurysm, AAA) OR abnormal PAD ultrasound or Doppler study results OR abnormal PAD angiography results.

Read codeRead termCALIBER category
2G63.00 Ischaemic toe Peripheral vascular disease
A3A0F00 Gas gangrene-foot Peripheral vascular disease
C107.00 Diabetes mellitus with peripheral circulatory disorder Peripheral vascular disease
C107000 Diabetes mellitus, juvenile +peripheral circulatory disorder Peripheral vascular disease
C107100 Diabetes mellitus, adult, + peripheral circulatory disorder Peripheral vascular disease
C107300 IDDM with peripheral circulatory disorder Peripheral vascular disease
C107400 NIDDM with peripheral circulatory disorder Peripheral vascular disease
C107z00 Diabetes mellitus NOS with peripheral circulatory disorder Peripheral vascular disease
C108G00 Insulin dependent diab mell with peripheral angiopathy Peripheral vascular disease
C109F00 Non-insulin-dependent d m with peripheral angiopath Peripheral vascular disease
C109F11 Type II diabetes mellitus with peripheral angiopathy Peripheral vascular disease
C109F12 Type 2 diabetes mellitus with peripheral angiopathy Peripheral vascular disease
C10EG00 Type 1 diabetes mellitus with peripheral angiopathy Peripheral vascular disease
C10FF00 Type 2 diabetes mellitus with peripheral angiopathy Peripheral vascular disease
G700.11 Aorto-iliac disease Peripheral vascular disease
G702.00 Extremity artery atheroma Peripheral vascular disease
G702z00 Extremity artery atheroma NOS Peripheral vascular disease
G73..00 Other peripheral vascular disease Peripheral vascular disease
G73..11 Peripheral ischaemic vascular disease Peripheral vascular disease
G73..12 Ischaemia of legs Peripheral vascular disease
G73..13 Peripheral ischaemia Peripheral vascular disease
G731.00 Thromboangiitis obliterans Peripheral vascular disease
G731000 Buerger's disease Peripheral vascular disease
G731z00 Thromboangiitis obliterans NOS Peripheral vascular disease
G732.00 Peripheral gangrene Peripheral vascular disease
G732000 Gangrene of toe Peripheral vascular disease
G732100 Gangrene of foot Peripheral vascular disease
G733.00 Ischaemic foot Peripheral vascular disease
G73y.00 Other specified peripheral vascular disease Peripheral vascular disease
G73y000 Diabetic peripheral angiopathy Peripheral vascular disease
G73y100 Peripheral angiopathic disease EC NOS Peripheral vascular disease
G73y200 Acrocyanosis Peripheral vascular disease
G73y400 Acroparaesthesia - Schultze's type Peripheral vascular disease
G73y500 Acroparaesthesia - Nothnagel's type Peripheral vascular disease
G73y511 Nothnagel's vasomotor acroparaesthesia Peripheral vascular disease
G73y600 Acroparaesthesia - unspecified Peripheral vascular disease
G73y700 Erythrocyanosis Peripheral vascular disease
G73y800 Erythromelalgia Peripheral vascular disease
G73yz00 Other specified peripheral vascular disease NOS Peripheral vascular disease
G73z.00 Peripheral vascular disease NOS Peripheral vascular disease
G73z000 Intermittent claudication Peripheral vascular disease
G73z011 Claudication Peripheral vascular disease
G73zz00 Peripheral vascular disease NOS Peripheral vascular disease
G740.12 Aortoiliac obstruction Peripheral vascular disease
G742z00 Peripheral arterial embolism and thrombosis NOS Peripheral vascular disease
Gyu7400 [X]Other specified peripheral vascular diseases Peripheral vascular disease
M271.12 Ischaemic leg ulcer Peripheral vascular disease
M271000 Ischaemic ulcer diabetic foot Peripheral vascular disease
M271300 Arterial leg ulcer Peripheral vascular disease
M271400 Mixed venous and arterial leg ulcer Peripheral vascular disease
R054200 [D]Gangrene of toe in diabetic Peripheral vascular disease
R054300 [D]Widespread diabetic foot gangrene Peripheral vascular disease
R055000 [D]Failure of peripheral circulation Peripheral vascular disease
R055011 [D]Peripheral circulatory failure Peripheral vascular disease
G742400 Embolism and thrombosis of the femoral artery Leg or aortic embolism or thrombosis
G742500 Embolism and thrombosis of the popliteal artery Leg or aortic embolism or thrombosis
G742600 Embolism and thrombosis of the anterior tibial artery Leg or aortic embolism or thrombosis
G742700 Embolism and thrombosis of the dorsalis pedis artery Leg or aortic embolism or thrombosis
G742900 Embolism and thrombosis of a leg artery NOS Leg or aortic embolism or thrombosis
G74y000 Embolism and/or thrombosis of the common iliac artery Leg or aortic embolism or thrombosis
G74y100 Embolism and/or thrombosis of the internal iliac artery Leg or aortic embolism or thrombosis
G74y200 Embolism and/or thrombosis of the external iliac artery Leg or aortic embolism or thrombosis
G74y300 Embolism and thrombosis of the iliac artery unspecified Leg or aortic embolism or thrombosis

Read codeRead termCALIBER category
7A10000 Emerg aortic bypass by anastomosis axillary to femoral art Other PAD procedures
7A10100 Bypass aorta by anastomosis axillary to femoral artery NEC Other PAD procedures
7A10200 Axillo-bifemoral bypass graft Other PAD procedures
7A10300 Axillo-unifemoral PTFE bypass graft Other PAD procedures
7A12.00 Other bypass of bifurcation of aorta Other PAD procedures
7A12000 Emerg bypass bifurc aorta by anast aorta to femoral artery Other PAD procedures
7A12100 Bypass bifurc aorta by anastom aorta to femoral artery NEC Other PAD procedures
7A12111 Aorto bifemoral graft Other PAD procedures
7A12112 Dacron aortofemoral Y graft Other PAD procedures
7A12300 Bypass bifurcation aorta by anastom aorta to iliac artery Other PAD procedures
7A12311 Aorto biiliac graft Other PAD procedures
7A12312 Dacron aortoiliac Y graft Other PAD procedures
7A12y00 Other specified other bypass of bifurcation of aorta Other PAD procedures
7A12z00 Other bypass of bifurcation of aorta NOS Other PAD procedures
7A19200 Open embolectomy of bifurcation of aorta Other PAD procedures
7A41.00 Other bypass of iliac artery Other PAD procedures
7A41000 Emerg bypass iliac art by iliac/femoral art anastomosis NEC Other PAD procedures
7A41100 Bypass iliac artery by iliac/femoral artery anastomosis NEC Other PAD procedures
7A41200 Emerg bypass iliac artery by femoral/femoral art anast NEC Other PAD procedures
7A41211 Emergency femoro-femoral prosthetic cross over graft Other PAD procedures
7A41300 Bypass iliac artery by femoral/femoral art anastomosis NEC Other PAD procedures
7A41311 Femoro-femoral prosthetic cross over graft Other PAD procedures
7A41400 Emerg bypass comm iliac art by aorta/com iliac art anast NEC Other PAD procedures
7A41600 Emerg bypass leg artery by aorta/com fem art anastomosis NEC Other PAD procedures
7A41900 Bypass common iliac artery by aorta/com iliac art anast NEC Other PAD procedures
7A41B00 Bypass leg artery by aorta/com femoral art anastomosis NEC Other PAD procedures
7A41C00 Bypass leg artery by aorta/deep femoral art anastomosis NEC Other PAD procedures
7A41F00 Ilio-femoral prosthetic cross over graft Other PAD procedures
7A41y00 Other specified other bypass of iliac artery Other PAD procedures
7A41z00 Other bypass of iliac artery NOS Other PAD procedures
7A42.00 Reconstruction of iliac artery Other PAD procedures
7A42.11 Reconstruction of common iliac artery Other PAD procedures
7A42000 Endarterectomy and patch repair of iliac artery Other PAD procedures
7A42011 Endarterectomy and patch repair of common iliac artery Other PAD procedures
7A42012 Iliac endarterectomy and patch Other PAD procedures
7A42100 Endarterectomy of iliac artery NEC Other PAD procedures
7A42111 Endarterectomy of common iliac artery NEC Other PAD procedures
7A42y00 Other specified reconstruction of iliac artery Other PAD procedures
7A42z00 Reconstruction of iliac artery NOS Other PAD procedures
7A43.00 Other open operations on iliac artery Other PAD procedures
7A43.11 Other open operations on common iliac artery Other PAD procedures
7A43000 Repair of iliac artery NEC Other PAD procedures
7A43011 Repair of common iliac artery NEC Other PAD procedures
7A43100 Open embolectomy of iliac artery Other PAD procedures
7A43111 Open embolectomy of common iliac artery Other PAD procedures
7A43300 Open insertion of iliac artery stent Other PAD procedures
7A44000 Percutaneous transluminal angioplasty of iliac artery Other PAD procedures
7A44100 Percutaneous transluminal embolectomy of iliac artery Other PAD procedures
7A44300 Insertion of iliac artery stent Other PAD procedures
7A44400 Percutaneous transluminal insertion of iliac artery stent Other PAD procedures
7A44y00 Other specified transluminal operation on iliac artery Other PAD procedures
7A44z00 Transluminal operation on iliac artery NOS Other PAD procedures
7A47.00 Other emergency bypass of femoral artery or popliteal artery Other PAD procedures
7A47.11 Other emerg bypass femoral or popliteal art by anastomosis Other PAD procedures
7A47.13 Other emergency bypass of deep femoral artery Other PAD procedures
7A47.14 Other emergency bypass of popliteal artery Other PAD procedures
7A47.15 Other emergency bypass of superficial femoral artery Other PAD procedures
7A47.16 Other emergency bypass of femoral artery Other PAD procedures
7A47000 Emerg bypass femoral art by fem/pop art anast c prosth NEC Other PAD procedures
7A47100 Emerg bypass popliteal art by pop/pop art anast c prosth NEC Other PAD procedures
7A47200 Emerg bypass femoral art by fem/pop a anast c vein graft NEC Other PAD procedures
7A47300 Emerg bypass pop art by pop/pop art anast c vein graft NEC Other PAD procedures
7A47400 Emerg bypass femoral art by fem/tib art anast c prosth NEC Other PAD procedures
7A47600 Emerg bypass femoral art by fem/tib a anast c vein graft NEC Other PAD procedures
7A47700 Emerg bypass pop art by pop/tib art anast c vein graft NEC Other PAD procedures
7A47B00 Emerg bypass pop art by pop/peron art anast c vein graft NEC Other PAD procedures
7A47C00 Emerg bypass femoral artery by fem/fem art anastomosis NEC Other PAD procedures
7A47D00 Emerg bypass popliteal artery by pop/fem art anastomosis NEC Other PAD procedures
7A47y00 Other emergency bypass of femoral or popliteal artery OS Other PAD procedures
7A47z00 Other emergency bypass of femoral or popliteal artery NOS Other PAD procedures
7A48.00 Other bypass of femoral artery or popliteal artery Other PAD procedures
7A48.11 Other bypass of femoral or popliteal artery by anastomosis Other PAD procedures
7A48.12 Other bypass of common femoral artery Other PAD procedures
7A48.14 Other bypass of femoral artery Other PAD procedures
7A48.15 Other bypass of popliteal artery Other PAD procedures
7A48.16 Other bypass of superficial femoral artery Other PAD procedures
7A48000 Bypass femoral artery by fem/pop art anast c prosthesis NEC Other PAD procedures
7A48100 Bypass popliteal artery by pop/pop a anast c prosthesis NEC Other PAD procedures
7A48200 Bypass femoral artery by fem/pop art anast c vein graft NEC Other PAD procedures
7A48300 Bypass popliteal artery by pop/pop a anast c vein graft NEC Other PAD procedures
7A48400 Bypass femoral artery by fem/tib art anast c prosthesis NEC Other PAD procedures
7A48500 Bypass popliteal artery by pop/tib a anast c prosthesis NEC Other PAD procedures
7A48600 Bypass femoral artery by fem/tib art anast c vein graft NEC Other PAD procedures
7A48700 Bypass popliteal artery by pop/tib a anast c vein graft NEC Other PAD procedures
7A48800 Bypass femoral artery by fem/peron a anast c prosthesis NEC Other PAD procedures
7A48A00 Bypass femoral artery by fem/peron a anast c vein graft NEC Other PAD procedures
7A48B00 Bypass popliteal art by pop/peron art anast c vein graft NEC Other PAD procedures
7A48C00 Bypass femoral artery by femoral/femoral art anastomosis NEC Other PAD procedures
7A48D00 Bypass popliteal artery by pop/fem artery anastomosis NEC Other PAD procedures
7A48E00 Femoro-femoral prosthetic cross over graft Other PAD procedures
7A48y00 Other bypass of femoral artery or popliteal artery OS Other PAD procedures
7A48z00 Other bypass of femoral artery or popliteal artery NOS Other PAD procedures
7A49.00 Reconstruction of femoral artery or popliteal artery Other PAD procedures
7A49.11 Reconstruction of common femoral artery Other PAD procedures
7A49.13 Reconstruction of femoral artery Other PAD procedures
7A49.14 Reconstruction of popliteal artery Other PAD procedures
7A49.15 Reconstruction of superficial femoral artery Other PAD procedures
7A49000 Endarterectomy and patch repair of femoral artery Other PAD procedures
7A49100 Endarterectomy and patch repair of popliteal artery Other PAD procedures
7A49200 Endarterectomy of femoral artery NEC Other PAD procedures
7A49300 Endarterectomy of popliteal artery NEC Other PAD procedures
7A49400 Profundoplasty femoral artery & patch repair deep fem artery Other PAD procedures
7A49500 Profundoplasty and patch repair of popliteal artery Other PAD procedures
7A49600 Profundoplasty of femoral artery NEC Other PAD procedures
7A49700 Profundoplasty of popliteal artery NEC Other PAD procedures
7A49800 Reconstruction of femoral artery with vein graft Other PAD procedures
7A49900 Reconstruction of popliteal artery with vein graft Other PAD procedures
7A49y00 Reconstruction of femoral or popliteal artery OS Other PAD procedures
7A49z00 Reconstruction of femoral or popliteal artery NOS Other PAD procedures
7A4A.00 Other open operations on femoral artery or popliteal artery Other PAD procedures
7A4A.11 Other open operations on common femoral artery Other PAD procedures
7A4A.13 Other open operations on popliteal artery Other PAD procedures
7A4A.14 Other open operations on superficial femoral artery Other PAD procedures
7A4A000 Repair of femoral artery NEC Other PAD procedures
7A4A100 Repair of popliteal artery NEC Other PAD procedures
7A4A200 Open embolectomy of femoral artery Other PAD procedures
7A4A211 Open thrombectomy of femoral artery Other PAD procedures
7A4A212 Open femoral embolectomy Other PAD procedures
7A4A300 Open embolectomy popliteal artery Other PAD procedures
7A4A311 Open thrombectomy of popliteal artery Other PAD procedures
7A4A700 Repair of femoral artery with temporary silastic shunt Other PAD procedures
7A4A800 Repair of popliteal artery with temporary silastic shunt Other PAD procedures
7A4Ay00 Other open operation on femoral or popliteal artery OS Other PAD procedures
7A4B000 Percutaneous transluminal angioplasty of femoral artery Other PAD procedures
7A4B100 Percutaneous transluminal angioplasty of popliteal artery Other PAD procedures
7A4B200 Percutaneous transluminal embolectomy of femoral artery Other PAD procedures
7A4B300 Percutaneous transluminal embolectomy of popliteal artery Other PAD procedures
7A4B400 Percutaneous transluminal embolisation of femoral artery Other PAD procedures
7A4B500 Percutaneous transluminal embolisation of popliteal artery Other PAD procedures
7A4B800 Percut translum thrombolysis femoral graft streptokinase Other PAD procedures
7A4B900 Percutaneous transluminal insertion of stent femoral artery Other PAD procedures
7A50.00 Revision of reconstruction of artery Other PAD procedures
7A50000 Revision of reconstruction involving aorta Other PAD procedures
7A50100 Revision of reconstruction involving iliac artery Other PAD procedures
7A50200 Revision of reconstruction involving femoral artery Other PAD procedures
7A50300 Revision of reconstruction of popliteal artery Other PAD procedures

Read codeRead termCALIBER category

Read codeRead termCALIBER category
5593.00 Femoral arteriogram abnormal Results abnormal
55A2.00 Lower limb arteriogram abnorm. Results abnormal
Read terms are hierarhically organized in top-level chapters i.e. chapter G....00 is related to Circulatory System Diseases and sub-headings i.e. heading G2...00 is related to Hypertensive Heart Disease while G3...00 is related to Ischaemic Heart Disease.

Secondary Care (incident and prevalent)

In Hospital Episode Statistics (HES, secondary care data) we used primary diagnosis of ICD-10 codes (see below) for PAD OR leg or aortic embolism or thrombosis OR PAD procedures (excluding repair of AAA).


ICD-10 codeICD-10 termCALIBER category
I731 Thromboangiitis obliterans [Buerger] Peripheral vascular disease
I738 Other specified peripheral vascular diseases Peripheral vascular disease
I739 Peripheral vascular disease, unspecified Peripheral vascular disease
I743 Embolism and thrombosis of arteries of lower extremities Leg or aortic embolism or thrombosis
I744 Embolism and thrombosis of arteries of extremities, unspecified Leg or aortic embolism or thrombosis
I745 Embolism and thrombosis of iliac artery Leg or aortic embolism or thrombosis

OPCS-4 codeOPCS-4 termCALIBER category
L50 Other emergency bypass of iliac artery PAD procedure performed
L50.1 Emergency bypass of common iliac artery by anastomosis of aorta to common iliac artery NEC PAD procedure performed
L50.2 Emergency bypass of iliac artery by anastomosis of aorta to external iliac artery NEC PAD procedure performed
L50.3 Emergency bypass of artery of leg by anastomosis of aorta to common femoral artery NEC PAD procedure performed
L50.4 Emergency bypass of artery of leg by anastomosis of aorta to deep femoral artery NEC PAD procedure performed
L50.5 Emergency bypass of iliac artery by anastomosis of iliac artery to iliac artery NEC PAD procedure performed
L50.6 Emergency bypass of artery of leg by anastomosis of iliac artery to femoral artery NEC PAD procedure performed
L50.8 Other specified other emergency bypass of iliac artery PAD procedure performed
L50.9 Unspecified other emergency bypass of iliac artery PAD procedure performed
L51 Other bypass of iliac artery PAD procedure performed
L51.1 Bypass of common iliac artery by anastomosis of aorta to common iliac artery NEC PAD procedure performed
L51.2 Bypass of iliac artery by anastomosis of aorta to external iliac artery NEC PAD procedure performed
L51.3 Bypass of artery of leg by anastomosis of aorta to common femoral artery NEC PAD procedure performed
L51.4 Bypass of artery of leg by anastomosis of aorta to deep femoral artery NEC PAD procedure performed
L51.5 Bypass of iliac artery by anastomosis of iliac artery to iliac artery NEC PAD procedure performed
L51.6 Bypass of artery of leg by anastomosis of iliac artery to femoral artery NEC PAD procedure performed
L51.8 Other specified other bypass of iliac artery PAD procedure performed
L51.9 Unspecified other bypass of iliac artery PAD procedure performed
L52 Reconstruction of iliac artery PAD procedure performed
L52.1 Endarterectomy of iliac artery and patch repair of iliac artery PAD procedure performed
L52.2 Endarterectomy of iliac artery NEC PAD procedure performed
L52.8 Other specified reconstruction of iliac artery PAD procedure performed
L52.9 Unspecified reconstruction of iliac artery PAD procedure performed
L53 Other open operations on iliac artery PAD procedure performed
L53.1 Repair of iliac artery NEC PAD procedure performed
L53.2 Open embolectomy of iliac artery PAD procedure performed
L54.1 Percutaneous transluminal angioplasty of iliac artery PAD procedure performed
L54.2 Percutaneous transluminal embolectomy of iliac artery PAD procedure performed
L54.4 Percutaneous transluminal insertion of stent into iliac artery PAD procedure performed
L54.8 Other specified transluminal operations on iliac artery PAD procedure performed
L54.9 Unspecified transluminal operations on iliac artery PAD procedure performed
L58 Other emergency bypass of femoral artery PAD procedure performed
L58.1 Emergency bypass of femoral artery by anastomosis of femoral artery to femoral artery NEC PAD procedure performed
L58.2 Emergency bypass of femoral artery by anastomosis of femoral artery to popliteal artery using prosthesis NEC PAD procedure performed
L58.3 Emergency bypass of femoral artery by anastomosis of femoral artery to popliteal artery using vein graft NEC PAD procedure performed
L58.4 Emergency bypass of femoral artery by anastomosis of femoral artery to tibial artery using prosthesis NEC PAD procedure performed
L58.5 Emergency bypass of femoral artery by anastomosis of femoral artery to tibial artery using vein graft NEC PAD procedure performed
L58.6 Emergency bypass of femoral artery by anastomosis of femoral artery to peroneal artery using prosthesis NEC PAD procedure performed
L58.7 Emergency bypass of femoral artery by anastomosis of femoral artery to peroneal artery using vein graft NEC PAD procedure performed
L58.8 Other specified other emergency bypass of femoral artery PAD procedure performed
L58.9 Unspecified other emergency bypass of femoral artery PAD procedure performed
L59 Other bypass of femoral artery PAD procedure performed
L59.1 Bypass of femoral artery by anastomosis of femoral artery to femoral artery NEC PAD procedure performed
L59.2 Bypass of femoral artery by anastomosis of femoral artery to popliteal artery using prosthesis NEC PAD procedure performed
L59.3 Bypass of femoral artery by anastomosis of femoral artery to popliteal artery using vein graft NEC PAD procedure performed
L59.4 Bypass of femoral artery by anastomosis of femoral artery to tibial artery using prosthesis NEC PAD procedure performed
L59.5 Bypass of femoral artery by anastomosis of femoral artery to tibial artery using vein graft NEC PAD procedure performed
L59.6 Bypass of femoral artery by anastomosis of femoral artery to peroneal artery using prosthesis NEC PAD procedure performed
L59.7 Bypass of femoral artery by anastomosis of femoral artery to peroneal artery using vein graft NEC PAD procedure performed
L59.8 Other specified other bypass of femoral artery PAD procedure performed
L59.9 Unspecified other bypass of femoral artery PAD procedure performed
L60 Reconstruction of femoral artery PAD procedure performed
L60.1 Endarterectomy of femoral artery and patch repair of femoral artery PAD procedure performed
L60.2 Endarterectomy of femoral artery NEC PAD procedure performed
L60.3 Profundoplasty of femoral artery and patch repair of deep femoral artery PAD procedure performed
L60.4 Profundoplasty of femoral artery NEC PAD procedure performed
L60.8 Other specified reconstruction of femoral artery PAD procedure performed
L60.9 Unspecified reconstruction of femoral artery PAD procedure performed
L62 Other open operations on femoral artery PAD procedure performed
L62.1 Repair of femoral artery NEC PAD procedure performed
L62.2 Open embolectomy of femoral artery PAD procedure performed
L62.8 Other specified other open operations on femoral artery PAD procedure performed
L62.9 Unspecified other open operations on femoral artery PAD procedure performed
L63.1 Percutaneous transluminal angioplasty of femoral artery PAD procedure performed
L63.2 Percutaneous transluminal embolectomy of femoral artery PAD procedure performed
L63.3 Percutaneous transluminal embolisation of femoral artery PAD procedure performed
L63.5 Percutaneous transluminal insertion of stent into femoral artery PAD procedure performed
L65 Revision of reconstruction of artery PAD procedure performed
L65.1 Revision of reconstruction involving aorta PAD procedure performed
L65.2 Revision of reconstruction involving iliac artery PAD procedure performed
L65.3 Revision of reconstruction involving femoral artery PAD procedure performed

In the Office for National Statistics (ONS) mortality register, we used ICD-10 and ICD-9 terms to identify fatal PAD cases where PAD diagnosis OR leg or aortic embolism or thrombosis was recorded as the underlying cause of death.

ICD-10 codeICD-10 termCALIBER category
I731 Thromboangiitis obliterans [Buerger] Peripheral vascular disease
I738 Other specified peripheral vascular diseases Peripheral vascular disease
I739 Peripheral vascular disease, unspecified Peripheral vascular disease
I743 Embolism and thrombosis of arteries of lower extremities Leg or aortic embolism or thrombosis
I744 Embolism and thrombosis of arteries of extremities, unspecified Leg or aortic embolism or thrombosis
I745 Embolism and thrombosis of iliac artery Leg or aortic embolism or thrombosis

ICD-9 codeICD-9 termCALIBER category
4431 Other peripheral vascular disease ; Thromboangiitis obliterans [Buerger's disease] Peripheral vascular disease
4438 Other peripheral vascular disease ; Other specified peripheral vascular diseases Peripheral vascular disease
4439 Other peripheral vascular disease ; Peripheral vascular disease, unspecified Peripheral vascular disease
4442 Arterial embolism and thrombosis ; Of arteries of the extremities Leg or aortic embolism or thrombosis
4448 Arterial embolism and thrombosis ; Of other specified artery Leg or aortic embolism or thrombosis

Combining evidence across sources to define and date phenotypes

Primary care
1. Peripheral vascular disease diagnosis during a consultation
2. Leg or aortic embolism or thrombosis diagnosis during a consultation
3. Peripheral arterial disease procedures, excluding repair of AAA recording during a consultation
4. Abnormal peripheral arterial disease (PAD) ultrasound or Doppler study results recorded during a consultation
5. Abnormal peripheral arterial disease angiography results recorded during a consultation

Secondary care
1. Primary diagnosis of Peripheral vascular disease during a hospitalization
2. Primary diagnosis of leg or aortic embolism or thrombosis during a hospitalization
3. Recording of peripheral arterial disease procedures, excluding repair of AAA

Mortality
1. Peripheral vascular disease as the underlying cause of death
2. Leg or aortic embolism or thrombosis as the underlying cause of death
Risk factor Publication
Sex How Does Cardiovascular Disease First Present in Women and Men? Incidence of 12 Cardiovascular Diseases in a Contemporary Cohort of 1,937,360 People. Circulation. 2015 Oct 6;132(14):1320-8. doi: 10.1161/CIRCULATIONAHA.114.013797. Epub 2015 Sep 1.
Type 2 diabetes Type 2 diabetes and incidence of a wide range of cardiovascular diseases: a cohort study in 1.9 million people. Lancet. 2015 Feb 26;385 Suppl 1:S86. doi: 10.1016/S0140-6736(15)60401-9.
Smoking Heterogeneous associations between smoking and a wide range of initial presentations of cardiovascular disease in 1937360 people in England: lifetime risks and implications for risk prediction. Int J Epidemiol. 2015 Feb;44(1):129-41. doi: 10.1093/ije/dyu218. Epub 2014 Nov 20.
Socioeconomic status Socioeconomic deprivation and the incidence of 12 cardiovascular diseases in 1.9 million women and men: implications for risk prediction and prevention. PLoS One. 2014 Aug 21;9(8):e104671. doi: 10.1371/journal.pone.0104671. eCollection 2014.
Blood pressure Blood pressure and incidence of twelve cardiovascular diseases: lifetime risks, healthy life-years lost, and age-specific associations in 1.25 million people. Lancet. 2014 May 31;383(9932):1899-911. doi: 10.1016/S0140-6736(14)60685-1.
Heart rate Archangelidi O et al. Clinically recorded heart rate and incidence of 12 coronary, cardiac, cerebrovascular and peripheral arterial diseases in 233,970 men and women: A linked electronic health record study. Eur J Prev Cardiol. 2018 Sep;25(14):1485-1495. doi: 10.1177/2047487318785228. Epub 2018 Jul 2.
Ethnicity George J et al. Ethnicity and the first diagnosis of a wide range of cardiovascular diseases: Associations in a linked electronic health record cohort of 1 million patients. PLoS One. 2017 Jun 9;12(6):e0178945. doi: 10.1371/journal.pone.0178945. eCollection 2017.
Alcohol Association between clinically recorded alcohol consumption and initial presentation of 12 cardiovascular diseases: population based cohort study using linked health records. BMJ. 2017 Mar 22;356:j909. doi: 10.1136/bmj.j909.
Giant cell arteritis Associations between polymyalgia rheumatica and giant cell arteritis and 12 cardiovascular diseases. Heart. 2016 Mar;102(5):383-9. doi: 10.1136/heartjnl-2015-308514. Epub 2016 Jan 19
Giant cell arteritis Associations between polymyalgia rheumatica and giant cell arteritis and 12 cardiovascular diseases. Heart. 2016 Mar;102(5):383-9. doi: 10.1136/heartjnl-2015-308514. Epub 2016 Jan 19
Neutrophils Neutrophil Counts and Initial Presentation of 12 Cardiovascular Diseases: A CALIBER Cohort Study. J Am Coll Cardiol. 2017 Mar 7;69(9):1160-1169. doi: 10.1016/j.jacc.2016.12.022.
Eosinophils Low eosinophil and low lymphocyte counts and the incidence of 12 cardiovascular diseases: a CALIBER cohort study. Open Heart. 2016 Sep 5;3(2):e000477. doi: 10.1136/openhrt-2016-000477. eCollection 2016.
Depression Depression as a Risk Factor for the Initial Presentation of Twelve Cardiac, Cerebrovascular, and Peripheral Arterial Diseases: Data Linkage Study of 1.9 Million Women and Men. PLoS One. 2016 Apr 22;11(4):e0153838. doi: 10.1371/journal.pone.0153838. eCollection 2016.
Polymyalgia rheumatica Associations between polymyalgia rheumatica and giant cell arteritis and 12 cardiovascular diseases. Heart. 2016 Mar;102(5):383-9. doi: 10.1136/heartjnl-2015-308514. Epub 2016 Jan 19
Lymphocytes Low eosinophil and low lymphocyte counts and the incidence of 12 cardiovascular diseases: a CALIBER cohort study. Open Heart. 2016 Sep 5;3(2):e000477. doi: 10.1136/openhrt-2016-000477. eCollection 2016.
Rheumatoid arthritis Rheumatoid Arthritis and Incidence of Twelve Initial Presentations of Cardiovascular Disease: A Population Record-Linkage Cohort Study in England. PLoS One. 2016 Mar 15;11(3):e0151245. doi: 10.1371/journal.pone.0151245.
Risk factor Publication
Sex How Does Cardiovascular Disease First Present in Women and Men? Incidence of 12 Cardiovascular Diseases in a Contemporary Cohort of 1,937,360 People. Circulation. 2015 Oct 6;132(14):1320-8. doi: 10.1161/CIRCULATIONAHA.114.013797. Epub 2015 Sep 1.
Type 2 diabetes Type 2 diabetes and incidence of a wide range of cardiovascular diseases: a cohort study in 1.9 million people. Lancet. 2015 Feb 26;385 Suppl 1:S86. doi: 10.1016/S0140-6736(15)60401-9.
Smoking Heterogeneous associations between smoking and a wide range of initial presentations of cardiovascular disease in 1937360 people in England: lifetime risks and implications for risk prediction. Int J Epidemiol. 2015 Feb;44(1):129-41. doi: 10.1093/ije/dyu218. Epub 2014 Nov 20.
Socioeconomic status Socioeconomic deprivation and the incidence of 12 cardiovascular diseases in 1.9 million women and men: implications for risk prediction and prevention. PLoS One. 2014 Aug 21;9(8):e104671. doi: 10.1371/journal.pone.0104671. eCollection 2014.
Blood pressure Blood pressure and incidence of twelve cardiovascular diseases: lifetime risks, healthy life-years lost, and age-specific associations in 1.25 million people. Lancet. 2014 May 31;383(9932):1899-911. doi: 10.1016/S0140-6736(14)60685-1.
Heart rate Archangelidi O et al. Clinically recorded heart rate and incidence of 12 coronary, cardiac, cerebrovascular and peripheral arterial diseases in 233,970 men and women: A linked electronic health record study. Eur J Prev Cardiol. 2018 Sep;25(14):1485-1495. doi: 10.1177/2047487318785228. Epub 2018 Jul 2.
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Alcohol Association between clinically recorded alcohol consumption and initial presentation of 12 cardiovascular diseases: population based cohort study using linked health records. BMJ. 2017 Mar 22;356:j909. doi: 10.1136/bmj.j909.
Giant cell arteritis Associations between polymyalgia rheumatica and giant cell arteritis and 12 cardiovascular diseases. Heart. 2016 Mar;102(5):383-9. doi: 10.1136/heartjnl-2015-308514. Epub 2016 Jan 19
Giant cell arteritis Associations between polymyalgia rheumatica and giant cell arteritis and 12 cardiovascular diseases. Heart. 2016 Mar;102(5):383-9. doi: 10.1136/heartjnl-2015-308514. Epub 2016 Jan 19
Neutrophils Neutrophil Counts and Initial Presentation of 12 Cardiovascular Diseases: A CALIBER Cohort Study. J Am Coll Cardiol. 2017 Mar 7;69(9):1160-1169. doi: 10.1016/j.jacc.2016.12.022.
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Polymyalgia rheumatica Associations between polymyalgia rheumatica and giant cell arteritis and 12 cardiovascular diseases. Heart. 2016 Mar;102(5):383-9. doi: 10.1136/heartjnl-2015-308514. Epub 2016 Jan 19
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Rheumatoid arthritis Rheumatoid Arthritis and Incidence of Twelve Initial Presentations of Cardiovascular Disease: A Population Record-Linkage Cohort Study in England. PLoS One. 2016 Mar 15;11(3):e0151245. doi: 10.1371/journal.pone.0151245.
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