CALIBER Multiple sclerosis phenotype

person Phenotype Multiple sclerosis
person Type Disease or syndrome
person Data sources Primary care (CPRD), hospital admission data (HES)
person Clinical Terminologies Read, ICD-9, ICD-10, Gemscript
person Valid event date range 01/01/1999 - 01/07/2016
person Sex Female/Male
person Agreed 23.11.2012 (Revision 2)
person Authors Mar Pujades-Rodriguez , Bram Duyx, Sara L. Thomas, Dimitris Stogiannis, Anisur Rahman, Liam Smeeth, Harry Hemingway

Primary Care (incident and prevalent)

In the Clinical Practice Research Datalink (CPRD, primary care data) we ascertained cases by searching for Read terms related to:

Diagnoses

Read codeRead termCALIBER category
F20..00 Multiple sclerosis Multiple sclerosis
F203.00 Exacerbation of multiple sclerosis Multiple sclerosis
F20..11 Disseminated sclerosis Multiple sclerosis
F20z.00 Multiple sclerosis NOS Multiple sclerosis
F202.00 Generalised multiple sclerosis Multiple sclerosis
F200.00 Multiple sclerosis of the brain stem Multiple sclerosis
666B.00 Multiple sclerosis multidisciplinary review Multiple sclerosis
666A.00 Multiple sclerosis review Multiple sclerosis
8CS1.00 Multiple sclerosis care plan agreed Multiple sclerosis
F201.00 Multiple sclerosis of the spinal cord Multiple sclerosis
Disease-modifying antirheumatic drugs (DMARD)

Product codeMedication
796 COPAXONE injection 20mg/1ml [TEVA]
13794 AVONEX powder for solution for injection 30micrograms [BIOGEN]
16722 interferon beta-1b powder for solution for injection 300micrograms (9.6million IU)
21261 interferon beta-1a powder for solution for injection 30micrograms
27388 AVONEX injection solution 30micrograms/0.5ml [BIOGEN]
28976 BETAFERON powder for solution for injection 300micrograms (9.6million IU) [SCHERING]
31179 glatiramer acetate injection 20mg/1ml
32608 interferon beta-1a injection 22micrograms (6million IU)
33725 interferon beta-1a injection solution 30micrograms/0.5ml
35421 REBIF injection 22micrograms (6million IU) [MERCK SER]
36081 REBIF injection solution 44micrograms (12 million IU) [MERCK SER]
38254 TYSABRI concentrate for solution for infusion 300mg/15ml [BIOGEN]
38444 interferon beta-1a injection solution 8.8micrograms + 22micrograms
38783 interferon beta-1a injection solution 44micrograms (12 million IU)
41191 natalizumab concentrate for solution for infusion 300mg/15ml

Read terms are hierarhically organized in top-level chapters i.e. chapter G....00 is related to Circulatory System Diseases and sub-headings i.e. heading G2...00 is related to Hypertensive Heart Disease while G3...00 is related to Ischaemic Heart Disease.

Secondary Care (incident and prevalent)

In Hospital Episode Statistics (HES, hospital admission data) we used ICD-10 terms (see below) for diagnosis when marked as the primary diagnosis i.e. the main condition treated or investigated during the relevant episode of healthcare. We used the date of admission to hospital as the date of the event. We additionally searched for OPCS-4 terms indicating releted procedures.

Diagnoses

ICD-10 codeICD-10 termCALIBER category
G35X Multiple sclerosis Multiple sclerosis
Not applicable.

Combining evidence across sources to define and date phenotypes

CALIBER multiple sclerosis Phenotype flowchart
Flow chart diagram illustrating the CALIBER phenotype algorithm for multiple sclerosis
Pujades-Rodriguez, Mar, Bram Duyx, Sara L. Thomas, Dimitris Stogiannis, Anisur Rahman, Liam Smeeth, and Harry Hemingway. "Rheumatoid arthritis and incidence of twelve initial presentations of cardiovascular disease: a population record-linkage cohort study in England." PLoS One 11, no. 3 (2016): e0151245.