CALIBER Hypetrophic Cardiomyopathy phenotype

person Phenotype Hypetrophic Cardiomyopathy
person Type Disease or syndrome
person Data sources Primary care (CPRD), hospital admission data (HES)
person Clinical Terminologies Read, OPCS-4
person Valid event date range 01/01/1999 - 01/07/2016
person Sex Female/Male
person Agreed 23.11.2012 (Revision 2)
person Authors Mar Pujades-Rodriguez, Oliver P. Guttmann, Arturo Gonzalez-Izquierdo, Bram Duyx, Constantinos O’Mahony, Perry Elliott, Harry Hemingway

Primary Care (incident and prevalent)

In the Clinical Practice Research Datalink (CPRD, primary care data) we ascertained cases by searching for Read terms related to:

Hypertrophic cardiomyopathy diagnoses

Read codeRead termCALIBER category
G551.00 Hypertrophic obstructive cardiomyopathy HCM
G554300 Hypertrophic non-obstructive cardiomyopathy HCM
Gyu5M00 [X]Other hypertrophic cardiomyopathy HCM
Hypertrophic cardiomyopathy family history

Read codeRead termCALIBER category
12CJ.00 FH: Cardiomyopathy Family history of cardiomyopathy
12CR.00 FH: Hypertrophic obstructive cardiomyopathy Family history of cardiomyopathy
Hypertrophic cardiomyopathy procedures

Read codeRead termCALIBER category
7937500 Implantation of internal cardiac defibrillator Cardioverter defibrillator implantation/renewal
793F300 Renewal of cardioverter defibrillator Cardioverter defibrillator implantation/renewal
7937600 Removal of internal cardiac defibrillator Cardioverter defibrillator removal
793F400 Removal of cardioverter defibrillator Cardioverter defibrillator removal
7936600 Implantation of permanent intravenous cardiac pacemaker Cardiac pacemaker implantation/renewal
7936700 Implantation of intravenous fixed-rate cardiac pacemaker Cardiac pacemaker implantation/renewal
7936B00 Implantation simple one wire intravenous cardiac pacemaker Cardiac pacemaker implantation/renewal
7936D00 Implantation complex two wire intravenous cardiac pacemaker Cardiac pacemaker implantation/renewal
793F200 Resiting of lead of cardioverter defibrillator Cardiac pacemaker implantation/renewal
ZV53300 [V]Fitting or adjustment of cardiac pacemaker Cardiac pacemaker implantation/renewal
SP00100 Mechanical complication of cardiac pacemaker Cardiac pacemaker testing
790C500 Percutaneous transluminal chemical mediated septal ablation Conductive heart system ablation
793M100 Perc transluminal ablation of atrial wall for atrial flutter Conductive heart system ablation
793M300 Perc translum ablat conduct sys heart for atrial flutter NEC Conductive heart system ablation
7L1H200 Internal electrode cardioversion Internal cardioversion
7L1H000 Direct current cardioversion External cardioversion
7L1H111 External electrode cardioversion External cardioversion
7L1H800 Chemical cardioversion Chemical cardioversion
Referral to specialist care

Read codeRead termCALIBER category
9NM2.00 Attending cardiology clinic Referral to a specialist
ZL5A100 Referral to cardiologist Referral to a specialist
Treatment

Read codeRead termCALIBER category
ZV1C200 [V]Personal history of long term (current) use of warfarin Indication of warfarin (no-prescription data)
67I8.00 Advice about taking aspirin Indication of aspirin (no-prescription data)
Arrhythmias related to hypertrophic cardiomyopathy

Read codeRead termCALIBER category
3272 ECG: atrial fibrillation Arrhythmia
3273 ECG: atrial flutter Arrhythmia
3283 ECG: ventricular fibrillation Arrhythmia
662S.00 Atrial fibrillation monitoring Arrhythmia
6A9..00 Atrial fibrillation annual review Arrhythmia
9hF..00 Exception reporting: atrial fibrillation quality indicators Arrhythmia
9hF1.00 Excepted from atrial fibrillation qual indic: Inform dissent Arrhythmia
9Os..00 Atrial fibrillation monitoring administration Arrhythmia
9Os0.00 Atrial fibrillation monitoring first letter Arrhythmia
9Os1.00 Atrial fibrillation monitoring second letter Arrhythmia
9Os2.00 Atrial fibrillation monitoring third letter Arrhythmia
9Os3.00 Atrial fibrillation monitoring verbal invite Arrhythmia
9Os4.00 Atrial fibrillation monitoring telephone invite Arrhythmia
G573.00 Atrial fibrillation and flutter Arrhythmia
G573000 Atrial fibrillation Arrhythmia
G573100 Atrial flutter Arrhythmia
G573200 Paroxysmal atrial fibrillation Arrhythmia
G573300 Non-rheumatic atrial fibrillation Arrhythmia
G573400 Permanent atrial fibrillation Arrhythmia
G573500 Persistent atrial fibrillation Arrhythmia
G573z00 Atrial fibrillation and flutter NOS Arrhythmia
G574.00 Ventricular fibrillation and flutter Arrhythmia
G574000 Ventricular fibrillation Arrhythmia
G574011 Cardiac arrest-ventricular fibrillation Arrhythmia
G574100 Ventricular flutter Arrhythmia
G574z00 Ventricular fibrillation and flutter NOS Arrhythmia
Hypertrophic cardiomyopathy symptoms

Read codeRead termCALIBER category
1736.00 Paroxysmal nocturnal dyspnoea HCM related symptom - Dyspnoea
2322.00 O/E - dyspnoea HCM related symptom - Dyspnoea
173D.00 Nocturnal dyspnoea HCM related symptom - Dyspnoea
173d.00 Work aggravated asthma HCM related symptom - Dyspnoea
R060800 [D]Shortness of breath HCM related symptom - Dyspnoea
R060A00 [D]Dyspnoea HCM related symptom - Dyspnoea
1812.00 Palpitations HCM related symptom - Palpitations
R051.00 [D]Palpitations HCM related symptom - Palpitations
2244.00 O/E - collapse - syncope HCM related symptom - Syncope
R002.11 [D]Syncope HCM related symptom - Syncope
R062000 [D]Cough syncope HCM related symptom - Syncope
1822.00 Central chest pain HCM related symptom - Chest pain
182..00 Chest pain HCM related symptom - Chest pain
R065.00 [D]Chest pain HCM related symptom - Chest pain
R065C00 [D]Retrosternal chest pain HCM related symptom - Chest pain
R065D00 [D]Central chest pain HCM related symptom - Chest pain
Ryu0400 [X]Other chest pain HCM related symptom - Chest pain
1837.00 Pitting oedema HCM related symptom - Oedema
1838.00 Sacral oedema HCM related symptom - Oedema
183..00 Oedema HCM related symptom - Oedema
22C..00 O/E - oedema HCM related symptom - Oedema
22C2.11 O/E - ankle oedema HCM related symptom - Oedema
22C3.11 O/E - foot oedema HCM related symptom - Oedema
22C4.11 O/E - leg oedema HCM related symptom - Oedema
23E1.00 O/E - pulmonary oedema HCM related symptom - Oedema
H541000 Chronic pulmonary oedema HCM related symptom - Oedema
R023.00 [D]Oedema HCM related symptom - Oedema
R023400 [D]Peripheral oedema HCM related symptom - Oedema

Prescriptions related to HCM

Amiodarone

Product codeMedication
188 amiodarone tablets 200mg
763 amiodarone tablets 100mg
7445 amiodarone injection 50mg/ml
8832 CORDARONE X tablets 200mg [SANOFI S]
12322 CORDARONE X tablets 100mg [SANOFI S]
17119 amiodarone injection 300mg/10ml
27161 AMIDOX tablets 200mg [BERK]
27193 CORDARONE X injection 150mg/3ml [SANOFI S]
29456 AMIODARONE tablets 200mg [SANDOZ]
31209 AMIODARONE tablets 100mg [HILLCROSS]
32164 AMIODARONE tablets 200mg [HILLCROSS]
32553 AMYBEN tablets 100mg [LEXON]
33119 amiodarone injection 150mg/3ml
34515 AMIODARONE tablets 200mg [GEN (UK)]
34751 AMIODARONE tablets 200mg [WINTHROP]
34851 AMIODARONE tablets 200mg [TEVA]
35517 amiodarone oral suspension 25mg/5ml
41530 AMIODARONE tablets 200mg [IVAX]
41551 AMIODARONE tablets 100mg [IVAX]
2716 disopyramide modified release tablet 150mg
2717 disopyramide capsules 100mg
4026 disopyramide modified release tablet 250mg
7482 RYTHMODAN capsules 100mg [SANOFI/AVE]
7727 RYTHMODAN capsules 150mg [SANOFI/AVE]
8632 RYTHMODAN RETARD tablets 250mg [SANOFI/AVE]
8760 disopyramide capsules 150mg
9713 disopyramide modified release capsules 250mg
10553 DIRYTHMIN SA DURULE 150mg [ASTRAZENEC]
12291 DISOPYRAMIDE 100 MG TAB
25482 RYTHMODAN injection 50mg/5ml [SANOFI/AVE]
26103 DISOPYRAMIDE 25 MG TAB
27321 ISOMIDE CR capsules 250mg [TILLOMED]
30433 disopyramide injection 50mg/5ml
41614 DISOPYRAMIDE capsules 100mg [HILLCROSS]
Aspirin

Product codeMedication
3 aspirin dispersible tablet 75mg
16 aspirin tablets 75mg
34 aspirin enteric coated tablets 75mg
111 ASPIRIN 40 MG CAP
216 ASPIRIN 70 MG TAB
254 aspirin tablets 300mg
306 aspirin with codeine phosphate and caffeine tablets
377 aspirin dispersible tablet 300mg
381 ANADIN tablets [WYETH CONS]
383 ASPIRIN 60 MG TAB
393 DISPRIN dispersible tablet 300mg [RECKITT B]
395 aspirin mixture
430 aspirin with caffeine capsules 500mg + 32mg
434 aspirin enteric coated tablets 300mg
484 EQUAGESIC tablets [WYETH PHAR]
645 aspirin suppository 300mg
657 aspirin granules 500mg
685 ASPAV dispersible tablet [ACTAVIS]
1049 NU-SEALS ASPIRIN tablets 600mg [LILLY]
1137 NU-SEALS ASPIRIN EC tablets 300mg [LILLY]
1486 ASPIRIN 75 MG SUP
1902 aspirin enteric coated tablets 600mg
2047 co-codaprin tablets 8mg+400mg
2105 SOLPRIN tablets 300mg [RECKITT B]
2237 benorilate tablets 750mg
2607 PAYNOCIL tablets [BEECHAM]
2628 NU-SEALS ASPIRIN EC tablets 75mg [LILLY]
2754 ASPIRIN SOLUBLE 150 MG TAB
2924 ASPIRIN 150 MG TAB
2986 co-codaprin dispersible tablet 8mg+400mg
3155 MIGRAVESS effervescent tablet 5mg + 325mg [BAYER]
3275 BENORAL sugar-free suspension 2g/5ml [SANOFI S]
3309 aspirin with caffeine tablets 325mg + 15mg
3386 MIGRAVESS FORTE effervescent tablet 5mg + 450mg [BAYER]
3726 metoclopramide with aspirin effervescent tablet 5mg + 325mg
4271 ASPIRIN SOLUBLE 200 MG TAB
4319 benorilate sugar-free suspension 2g/5ml
4523 ASPIRIN 50 MG CAP
4557 ASPIRIN & PAPAVERUTUM 10 MG TAB
4679 ASASANTIN RETARD capsules 200mg + 25mg [BOEH INGL]
5288 MIGRAMAX powder for oral solution 900mg + 10mg [CEPHALON]
6006 NU-SEALS ASPIRIN EC tablets 75mg [ALLIANCE]
6007 NU-SEALS ASPIRIN EC tablets 300mg [ALLIANCE]
6226 papaveretum with aspirin dispersible tablet 7.71mg + 500mg
6666 dipyridamole with aspirin modified release capsules 200mg + 25mg
6696 MICROPIRIN enteric coated tablets 75mg [DEXCEL]
7417 ASPIRIN 40 MG TAB
7462 ASPIRIN 325 MG CAP
7486 ASPIRIN 37.5 MG TAB
7516 aspirin effervescent tablet 300mg
7518 aspirin with codeine dispersible tablet 400mg + 8mg
7520 ANADIN EXTRA soluble tablet [WYETH CONS]
7539 BEECHAMS powders [GLAXSK CON]
7665 ASPIRIN SR 300 MG TAB
7769 ASPIRIN/PARACETAMOL TAB
7770 ASPIRIN/CODEINE PHOSPHATE/PARACETAMOL 250 MG TAB
7915 ASPIRIN SR 100 MG TAB
7944 ASPIRIN SOLUBLE 40 MG CAP
7989 DIHYDROCODEINE TARTRATE/ASPIRIN 300 MG TAB
8185 DISPRIN CV modified release tablet 300mg [RECKITT B]
8186 aspirin modified release tablet 300mg
8271 BENORAL tablets 750mg [SANOFI S]
8381 ASPIRIN /CAMPHOR /MENTHOL /METHYL SALICY 1.2 % LIN
8424 ASPIRIN PAED 81 MG TAB
8645 aspirin effervescent tablets 300mg
8733 JUNIOR ASPIRIN 37.5 MG TAB
8734 ASPIRIN disp 37.5 MG TAB
8843 ASPIRIN 325 MG TAB
8920 ASPIRIN SOLUBLE 500 MG TAB
9027 ASPIRIN disp 150 MG TAB
9044 CODIS 500 tablets [RECKITT B]
9129 paracetamol with aspirin and codeine tablets 250mg+250mg+6.8mg
9144 CAPRIN EC tablets 75mg [WOCKHARDT]
9301 aspirin modified release tablet 100mg
9432 aspirin with codeine soluble tablet 500mg + 8mg
9939 aspirin soluble tablet 500mg
10031 aspirin with dipyridamole modified release capsules 25mg + 200mg
10298 BENORAL granules 2g/sachet [SANOFI S]
10305 aspirin capsules 162.5mg
10310 aspirin powder
11326 meprobamate with ethoheptazine citrate and aspirin tablets
11941 ASPIRIN SACHETS 30 MG
11951 PHENSIC tablets [MERCK CONS]
11961 VEGANIN tablets [PFIZER]
11977 ASPRO CLEAR maximum strength tablets [BAYER]
12047 ASPELLIN liniment [RPR/FISONS]
12102 ASPIRIN SOLUBLE 100 MG TAB
12605 ASPIRIN & CAFFEINE disp 300 MG TAB
12964 aspirin with caffeine powders 600mg + 50mg
12976 lysine acetylsalicylate with metoclopramide powder for oral solution 900mg + 10mg
12992 co-codaprin soluble tablet 8mg+500mg
13598 ASPIRIN & CODEINE 500 MG TAB
13882 IMAZIN XL modified release tablet 60mg + 75mg [NAPPPHARM]
14517 ROBAXISAL FORTE tablets [SHIRE]
15044 ASPIRIN disp 500 MG TAB
15352 ASPIRIN & PARACETAMOL TAB
15364 aspirin suppository 150mg
15367 ANADIN EXTRA tablets [WYETH CONS]
15397 ASPIRIN SOLUBLE 50 MG TAB
15447 ASPIRIN SOLUBLE 600 MG TAB
15517 ASPIRIN 100 MG SUP
15779 codeine phosphate with aspirin soluble tablet 8mg + 500mg
16184 ALKA-SELTZER tablets [BAYER]
16611 ANADIN caplets [WYETH CONS]
17180 metoclopramide with aspirin effervescent tablet 5mg + 450mg
17456 metoclopramide with lysine acetylsalicylate powder for oral solution 10mg + 900mg
17704 PLATET effervescent tablet 100mg [ROCHE]
17920 DISPRIN CV modified release tablet 100mg [RECKITT B]
17926 aspirin with codeine tablets 400mg + 8mg
18030 IMAZIN XL FORTE modified release tablet 60mg + 150mg [NAPPPHARM]
18217 aspirin orodispersible tablet 300mg
18261 aspirin with papaveretum dispersible tablet 500mg + 7.71mg
18329 ENPRIN enteric coated tablets 75mg [GALPHARM]
19189 MICROPIRIN enteric coated tablets 75mg [RATIOPHARM]
19255 paracetamol with aspirin and caffeine tablets 200mg + 300mg +45mg
19577 NU-SEALS ASPIRIN
19674 ASPIRIN DISPERSIBLE
19724 ASPIRIN & CODEINE paed 75 MG TAB
19797 NU-SEALS ASPIRIN
19813 ASPIRIN SOLUBLE
20127 codeine phosphate with aspirin dispersible tablet 8mg+400mg
20206 ASPIRIN 50 MG SUP
20650 aspirin with paracetamol dispersible tablet 300mg + 200mg
20840 acetylsalicylic acid mixture
21067 DOLOXENE COMPOUND capsules [LILLY]
21380 isosorbide mononitrate with aspirin modified release tablet 60mg + 75mg
21382 isosorbide mononitrate with aspirin modified release tablet 60mg + 150mg
21770 paracetamol with aspirin dispersible tablet 200mg + 300mg
21921 POSTMI EC tablets 300mg [ASHBOURNE]
21932 ETHOHEPTALINE CITRATE/ASPIRIN MG TAB
22107 ASPIRIN disp 200 MG TAB
22138 aspirin modified release tablet 324mg
22232 DISPRIN DIRECT orodispersible tablet [RECKITT B]
22253 ASPIRIN paed 150 MG SUP
22305 DISPRIN EXTRA dispersible tablet [RECKITT B]
22450 ASPIRIN & CODEINE 75 MG TAB
22618 SOLPRIN tablets 75mg [RECKITT B]
22776 aspirin with cyclizine effervescent tablet 500mg+25mg
22824 ASPIRIN disp 600 MG TAB
22863 ASPIRIN S/R 500 MG TAB
22864 ASPIRIN PAED MIX
23142 benorilate granules 2g/sachet
23250 ASPIRIN /ETHOHEPTAZINE CITRATE /MEPROBAM 250 MG TAB
23488 CLARADIN tablets 300mg [NICHOLAS]
23491 ASPIRIN 500 MG SUP
23495 ASPIRIN
23593 POSTMI dispersible tablet 75mg [ASHBOURNE]
23841 SAFAPRYN tablets [PFIZER]
23878 NU-SEALS CARDIO EC tablets 75mg [GENUS]
23932 ASPRO CLEAR effervescent tablet 300mg [BAYER]
24025 CAPRIN EC tablets 300mg [PINEWOOD]
24309 paracetamol with aspirin and caffeine powders 120mg + 165.3mg + 60mg
24427 ANHYDROUS CITRIC ACID /ASPIRIN /CALCIUM 8 MG TAB
24498 ASPIRIN/CODEINE PHOSPHATE/PARACETAMOL 300 MG TAB
24622 aspirin with caffeine tablets 325mg + 22mg
24828 HYPON tablets [WELLCOME]
24857 ASPIRIN 250 MG SUP
24960 ASPIRIN tablets 300mg [AAH(VANT)]
25211 ANADIN ORIGINAL tablets [WYETH CONS]
25335 POSTMI EC tablets 75mg [ASHBOURNE]
25718 ANGETTES tablets 75mg [BRISTOL]
25959 ASPIRIN/CAFFEINE/DEXTROPROPOXYPHENE NAPS PUL
26099 ASPIRIN 175 MG SUP
26424 ASPIRIN 200 MG SUP
26582 ASPIRIN PAED 100 MG SUP
26792 ASPIRIN 125 MG SUP
26967 ALKA-SELTZER XS effervescent tablet [BAYER]
27435 paracetamol with aspirin and caffeine soluble tablet 200mg + 300mg +45mg
27467 ASPIRIN SOLUBLE 400 MG TAB
28238 ASPIRIN 300MG/LYSINE 245MG 300 MG TAB
28606 ASPIRIN/CAFFEINE/CODEINE PHOSPHATE 300 MG TAB
28707 ASPIRIN M/F 324 MG TAB
28784 codeine phosphate with aspirin tablets 8mg+400mg
28810 aspirin with glycine dissolving tablets 300mg + 133mg
29054 methocarbamol with aspirin tablets
29759 ASPRO tablets [ROCHE]
29848 aspirin with glycine chewable tablet 300mg + 150mg
30022 FYNNON CALCIUM ASPIRIN soluble tablet 500mg [SSL INT]
30432 ASPIRIN & DOVERS pwdr TAB
30695 ASPIRIN 120 MG SUP
30920 ASPIRIN dispersible tablet 300mg [M&A PHARM]
31001 CULLENS HEADACHE POWDERS sachets [CULL&DAVID]
31210 ASPIRIN tablets 300mg [CO-OPERATI]
31211 ASPIRIN dispersible tablet 75mg [AAH(VANT)]
31498 ASPIRIN / CAFFEINE CIT./ CODEINE PHOS./ 200 MG TAB
31499 paracetamol with aspirin tablets
31858 CASPAC XL capsules 162.5mg [PHARMACIA]
31870 aspirin tablets 320mg
31894 SAFAPRYN -CO tablets [PFIZER]
31938 ASPIRIN EC tablets 75mg [SANDOZ]
31953 ASPIRIN dispersible tablet 75mg [IVAX]
31954 ASPIRIN dispersible tablet 75mg [TEVA]
31956 ASPIRIN enteric coated tablets 75mg [KENT]
32036 ASPIRIN dispersible tablet 75mg [ACTAVIS]
32154 ANADIN soluble tablet [WYETH CONS]
32178 paracetamol with aspirin and caffeine effervescent tablet 133mg + 267mg +40mg
32210 ASPIRIN dispersible tablet 300mg [ACTAVIS]
32314 aspirin with aloxiprin and caffeine powder
32728 ASKIT powder [BAYER]
32992 ASPIRIN enteric coated tablets 75mg [GEN (UK)]
33075 ASPIRIN 600MG/GLYCINE 300MG 600 MG TAB
33139 ANADIN MAXIMUM STRENGTH capsules [WYETH CONS]
33293 ASPIRIN enteric coated tablets 75mg [STERWIN]
33317 aspirin with sodium bicarbonate and citric acid effervescent tablet
33320 ASPIRIN dispersible tablet 75mg [SOVEREIGN]
33656 ASPIRIN dispersible tablet 75mg [HILLCROSS]
33662 ASPIRIN dispersible tablet 300mg [AAH(VANT)]
33668 ASPIRIN dispersible tablet 300mg [RUSCO]
33676 ASPIRIN dispersible tablet 75mg [KENT]
34233 aspirin with aloxiprin and caffeine capsules
34309 ASPIRIN dispersible tablet 300mg [HILLCROSS]
34385 ASPIRIN soluble tablet 75mg [CO-OPERATI]
34386 ASPIRIN tablets 300mg [ACTAVIS]
34434 ASPIRIN dispersible tablet 75mg [T&R CARE]
34485 ASPIRIN enteric coated tablets 75mg [IVAX]
34611 ASPIRIN enteric coated tablets 75mg [CP PHARM]
34666 ASPIRIN EC tablets 300mg [AAH(VANT)]
34762 ASPIRIN enteric coated tablets 300mg [GALEN]
34796 ASPIRIN enteric coated tablets 75mg [GALEN]
34797 ASPIRIN enteric coated tablets 75mg [ACTAVIS]
34942 ASPIRIN dispersible tablet 75mg [NUCARE]
35967 EXTRA POWER PAIN CONTROL caplets [GALPHARM]
36521 aspirin modified release tablet 500mg
36543 aspirin effervescent tablets 100mg
37541 aspirin chewing gum 227mg
39738 aspirin modified release capsules 162.5mg
40144 ASPIRIN dispersible tablet 300mg [T & R]
40191 ASPIRIN /CAFFEINE /QUININE SULPHATE 325 MG TAB
40381 ASPIRIN soluble tablet 75mg [CP PHARM]
41512 ASPIRIN enteric coated tablets 75mg [TEVA]
41569 ASPIRIN tablets 300mg [HILLCROSS]
41594 ASPIRIN dispersible tablet 300mg [TEVA]
41766 ASPRO CLEAR MAXIMUM STRENGTH tablets [BAYER]
489 clopidogrel film coated tablets 75mg
836 PLAVIX film coated tablets 75mg [SANOFI BMS]
17817 CLOPIDOGREL FC
38349 clopidogrel film coated tablets 300mg
38998 PLAVIX film coated tablets 300mg [SANOFI BMS]
40913 GREPID film coated tablets 75mg [BEACON]
Beta blockers

Product codeMedication
472 bisoprolol tablets 5mg
594 bisoprolol tablets 2.5mg
599 bisoprolol tablets 1.25mg
739 metoprolol tartrate tablets 50mg
753 metoprolol tartrate tablets 100mg
817 carvedilol tablets 3.125mg
822 bisoprolol oral suspension 1.5mg/5ml
1290 bisoprolol tablets 10mg
2629 carvedilol tablets 12.5mg
3588 MONOCOR tablets 5mg [WYETH PHAR]
4410 carvedilol tablets 6.25mg
4771 EMCOR LS tablets 5mg [MERCK SER]
5713 bisoprolol tablets 7.5mg
5968 MONOCOR tablets 10mg [WYETH PHAR]
7049 carvedilol tablets 25mg
7066 metoprolol tartrate with hydrochlorothiazide tablets 100mg + 12.5mg
7091 bisoprolol tablets 3.75mg
7553 bisoprolol oral suspension 5mg/5ml
8068 metoprolol tartrate modified release tablet 200mg
10892 EMCOR tablets 10mg [MERCK SER]
11793 metoprolol tartrate suspension 50mg/5ml
14030 CARDICOR tablets 2.5mg [MERCK SER]
14058 CARDICOR tablets 1.25mg [MERCK SER]
14117 EUCARDIC tablets 3.125mg [ROCHE]
14146 EUCARDIC tablets 6.25mg [ROCHE]
14502 metoprolol tartrate injection 5mg/5ml
15488 metoprolol tartrate with chlortalidone tablets
17462 bisoprolol and hydrochlorothiazide tablets 10mg + 6.25mg
17615 CARDICOR tablets 5mg [MERCK SER]
17876 METOPROLOL FUMARATE 190 MG TAB
18185 CARDICOR tablets 7.5mg [MERCK SER]
18414 EUCARDIC tablets 12.5mg [ROCHE]
18722 CARVEDILOL
19178 BISOPROLOL tablets 10mg [RANBAXY]
19200 BISOPROLOL tablets 5mg [IVAX]
19202 CARVEDILOL tablets 6.25mg [TEVA]
19437 EUCARDIC tablets 25mg [ROCHE]
19853 CARDICOR tablets 3.75mg [MERCK SER]
19858 CARDICOR tablets 10mg [MERCK SER]
20093 metoprolol tartrate with hydrochlorothiazide modified release tablet 200mg + 25mg
21905 BIPRANIX tablets 10mg [ASHBOURNE]
21966 BIPRANIX tablets 5mg [ASHBOURNE]
22151 METOPROLOL 100MG/CHLORTHALIDONE 12.5MG
22796 CARVEDILOL 3.125 MG
24083 BISOPROLOL tablets 5mg [TEVA]
24520 HYDROCHLOROTHIAZIDE /METOPROLOL TARTRATE 25 MG TAB
28493 METOPROLOL FUMARATE 95 MG TAB
29427 hydrochlorothiazide with metoprolol tartrate tablets 12.5mg + 100mg
32114 BISOPROLOL tablets 5mg [GEN (UK)]
32552 CONGESCOR tablets 2.5mg [TILLOMED]
32630 VIVACOR tablets 10mg [LEXON]
32836 METOPROLOL tablets 50mg [GEN (UK)]
33374 CARVEDILOL tablets 12.5mg [GENUS]
33659 hydrochlorothiazide with metoprolol tartrate modified release tablet 25mg + 200mg
33839 BISOPROLOL tablets 10mg [ACTAVIS]
33909 CONGESCOR tablets 1.25mg [TILLOMED]
34092 METOPROLOL tablets 100mg [TEVA]
34094 METOPROLOL tablets 50mg [HILLCROSS]
34125 METOPROLOL tablets 100mg [HILLCROSS]
34407 METOPROLOL tablets 50mg [TEVA]
34430 METOPROLOL tablets 50mg [ACTAVIS]
34501 CARVEDILOL tablets 12.5mg [ACTAVIS]
34509 METOPROLOL tablets 100mg [GEN (UK)]
34584 METOPROLOL tablets 50mg [IVAX]
34740 CARVEDILOL tablets 6.25mg [ACTAVIS]
34741 CARVEDILOL tablets 3.125mg [IVAX]
34821 BISOPROLOL tablets 10mg [GEN (UK)]
34854 METOPROLOL tablets 100mg [ACTAVIS]
34890 METOPROLOL tablets 50mg [BERK]
34925 METOPROLOL tablets 50mg [SANDOZ]
34963 BISOPROLOL tablets 5mg [ACTAVIS]
37118 BISOPROLOL tablets 2.5mg [HILLCROSS]
37837 BISOPROLOL tablets 2.5mg [TEVA]
38991 BISOPROLOL tablets 7.5mg [HILLCROSS]
39646 bisoprolol oral liquid 0.625mg/5ml
39846 VIVACOR tablets 5mg [LEXON]
40167 METOPROLOL tablets 100mg [IVAX]
41591 BISOPROLOL tablets 10mg [TEVA]
Calcium channel blockers

Product codeMedication
219 diltiazem 12 hour modified release tablets 120mg
517 ADIZEM SR capsules 120mg [NAPPPHARM]
536 TILDIEM LA capsules 200mg [SANOFI S]
636 diltiazem 12 hour modified release capsules 60mg
700 VERA-TIL SR tablets 120mg [TILLOMED]
793 ADIZEM XL capsules 240mg [NAPPPHARM]
939 TILDIEM RETARD tablets 90mg [SANOFI S]
1118 verapamil hydrochloride tablets 40mg
1120 verapamil hydrochloride tablets 80mg
1130 VIAZEM XL capsules 300mg [GENUS]
1289 TILDIEM RETARD tablets 120mg [SANOFI S]
1298 verapamil hydrochloride modified release tablet 240mg
1538 diltiazem tablets 60mg
1574 verapamil hydrochloride modified release capsules 120mg
1686 diltiazem 12 hour modified release capsules 90mg
1747 verapamil hydrochloride tablets 120mg
1748 CORDILOX tablets 120mg [IVAX]
1836 diltiazem 8 hour modified release tablets 60mg
1995 diltiazem 12 hour modified release capsules 120mg
2453 diltiazem modified release capsules 60mg
2528 SLOZEM capsules 120mg [MERCK SER]
2592 VIAZEM XL capsules 120mg [GENUS]
2663 diltiazem modified release capsules 240mg
2686 DILZEM XL MR capsules 240mg [ELANPHARMA]
2811 ADIZEM SR capsules 180mg [NAPPPHARM]
2888 TILDIEM modified release tablet 60mg [SANOFI S]
3057 SECURON tablets 120mg [ABBOTT]
3061 diltiazem 12 hour modified release capsules 180mg
3118 ADIZEM SR capsules 90mg [NAPPPHARM]
3342 SECURON SR tablets 240mg [ABBOTT]
3343 HALF SECURON SR tablets 120mg [ABBOTT]
3370 DILZEM XL MR capsules 120mg [ELANPHARMA]
3676 DILZEM XL MR capsules 180mg [ELANPHARMA]
3943 verapamil hydrochloride modified release capsules 240mg
4308 DILZEM SR capsules 90mg [ELANPHARMA]
4408 SLOZEM capsules 240mg [MERCK SER]
4635 diltiazem 24 hour modified release capsules 200mg
4732 diltiazem 12 hour modified release tablets 90mg
4808 diltiazem 24 hour modified release capsules 240mg
4852 ADIZEM SR tablets 120mg [NAPPPHARM]
4923 diltiazem 24 hour modified release capsules 180mg
5054 ANGITIL SR capsules 180mg [CHIESI]
5194 DILZEM SR capsules 120mg [ELANPHARMA]
5234 SLOZEM capsules 180mg [MERCK SER]
5296 TILDIEM LA capsules 300mg [SANOFI S]
5326 diltiazem 24 hour modified release capsules 300mg
5348 diltiazem 24 hour modified release capsules 300mg
5513 DILZEM SR capsules 60mg [ELANPHARMA]
6309 ADIZEM XL capsules 300mg [NAPPPHARM]
6510 UNIVER sustained release capsules 120mg [CEPHALON]
7398 VIAZEM XL capsules 360mg [GENUS]
8024 DILTIAZEM HCl XL 300 MG CAP
8524 SECURON tablets 40mg [ABBOTT]
8558 ADIZEM XL capsules 120mg [NAPPPHARM]
8759 verapamil hydrochloride modified release tablet 120mg
8884 CORDILOX tablets 40mg [IVAX]
8945 UNIVER sustained release capsules 240mg [CEPHALON]
8975 verapamil hydrochloride modified release capsules 180mg
9094 DILTIAZEM HCl SR 300 MG CAP
9240 ADIZEM XL capsules 180mg [NAPPPHARM]
9374 ADIZEM modified release tablet 60mg [NAPPPHARM]
9410 ANGITIL SR capsules 120mg [CHIESI]
9569 verapamil hydrochloride modified release tablet 120mg
9708 diltiazem 24 hour modified release capsules 120mg
9723 CALCICARD CR controlled release tablet 90mg [IVAX]
9919 diltiazem cream 2%
10267 ADIZEM XL capsules 200mg [NAPPPHARM]
10688 verapamil hydrochloride tablets 160mg
10832 SECURON tablets 80mg [ABBOTT]
10897 VERAPAMIL S/F 40 MG/5ML SOL
11223 ANGITIL SR capsules 90mg [CHIESI]
11770 DILZEM SR capsules 60mg [CEPHALON]
11777 verapamil hydrochloride sugar free solution 40mg/5ml
11922 diltiazem oral suspension 60mg/5ml
11972 VERTAB SR tablets 240mg [CHIESI]
11973 CALCICARD CR controlled release tablet 120mg [IVAX]
12104 CORDILOX tablets 160mg [IVAX]
12392 UNIVER sustained release capsules 180mg [CEPHALON]
12639 DILTIAZEM HYDROCHLORIDE modified release tablet 90mg [ACTAVIS]
12705 ANGIOZEM CR slow-release tablets 90mg [ASHBOURNE]
13027 VIAZEM XL capsules 240mg [GENUS]
13033 ANGITIL XL capsules 240mg [CHIESI]
13075 DILZEM XL capsules 180mg [CEPHALON]
13127 DILZEM XL capsules 240mg [CEPHALON]
13240 DILZEM XL capsules 120mg [CEPHALON]
13251 VERA-TIL SR tablets 240mg [TILLOMED]
13302 DILZEM SR capsules 90mg [CEPHALON]
13410 ANGIOZEM tablets 60mg [ASHBOURNE]
13856 VERAPRESS MR tablets 240mg [ACTAVIS]
13926 diltiazem 24 hour modified release capsules 360mg
13965 CORDILOX MR tablets 240mg [IVAX]
14892 ANOHEAL cream 2% [SLA PHARMA]
15221 DILCARDIA XL modified release capsules 180mg [GEN (UK)]
15288 ANGITIL XL capsules 300mg [CHIESI]
15659 DILTIAZEM HCL S/R 180 CAP
16038 DILZEM SR capsules 120mg [CEPHALON]
16328 VERAPRESS modified release tablet 240mg [DEXCEL]
16677 CORDILOX tablets 80mg [IVAX]
16850 ANGIOZEM CR slow-release tablets 120mg [ASHBOURNE]
17406 ZEMTARD XL capsules 180mg [GALEN]
17425 ZEMTARD XL capsules 120mg [GALEN]
17492 ZEMTARD XL capsules 300mg [GALEN]
17586 SLOZEM capsules 300mg [MERCK SER]
17599 VERAPRESS MR tablets 240mg [SANDOZ]
17666 VIAZEM XL capsules 180mg [GENUS]
18223 trandolapril with verapamil modified release capsules 2mg + 180mg
18379 DILCARDIA SR modified release capsules 90mg [GEN (UK)]
18403 DILTIAZEM HYDROCHLORIDE modified release capsules 180mg [HILLCROSS]
18404 DILTIAZEM HYDROCHLORIDE SR capsules 60mg [HILLCROSS]
18606 diltiazem and hydrochlorothiazide modified release capsules 150mg + 12.5mg
18631 VERAPAMIL HCL MR
18830 DISOGRAM SR capsules 90mg [RANBAXY]
18834 DISOGRAM SR capsules 60mg [RANBAXY]
18852 DISOGRAM SR capsules 120mg [RANBAXY]
18874 DISOGRAM SR capsules 180mg [RANBAXY]
18975 CALCICARD tablets 60mg [3M]
19175 VERAPAMIL HYDROCHLORIDE tablets 40mg [IVAX]
19325 CORDILOX injection 2.5mg/ml [IVAX]
19426 DISOGRAM SR capsules 240mg [RANBAXY]
19440 DISOGRAM SR capsules 300mg [RANBAXY]
19457 RANVERA MR tablets 240mg [RANBAXY]
19459 VERAPAMIL HYDROCHLORIDE modified release tablet 240mg [HILLCROSS]
19690 verapamil hydrochloride with trandolapril modified release capsules 180mg + 2mg
20579 TARKA capsules 180mg + 2mg [ABBOTT]
20642 BI-CARZEM SR capsules 60mg [TILLOMED]
20890 ZEMTARD XL capsules 240mg [GALEN]
21145 DILCARDIA SR modified release capsules 60mg [GEN (UK)]
21763 DILTIAZEM HYDROCHLORIDE tablets 60mg [HILLCROSS]
21773 DILTIAZEM HYDROCHLORIDE tablets 60mg [GEN (UK)]
21778 DILTIAZEM HYDROCHLORIDE tablets 60mg [APS]
21795 RETALZEM modified release tablet 60mg [KENT]
21918 OPTIL modified release tablet 60mg [OPUS]
22619 BRITIAZIM modified release tablet 60mg [THAMES]
22826 SECURON tablets 160mg [ABBOTT]
23233 BI-CARZEM SR capsules 90mg [TILLOMED]
23458 VERAPAMIL SR
23505 ADIZEM XL PLUS controlled release capsules 150mg + 12.5mg [NAPP]
23730 VERAPAMIL 100 MG TAB
23733 OPTIL SR sustained release capsules 90mg [OPUS]
23872 BERKATENS tablets 40mg [BERK]
25059 BERKATENS tablets 80mg [BERK]
25777 DILCARDIA SR modified release capsules 120mg [GEN (UK)]
26252 BERKATENS tablets 160mg [BERK]
26267 OPTIL SR sustained release capsules 120mg [OPUS]
26269 OPTIL SR sustained release capsules 180mg [OPUS]
26270 OPTIL XL extra sustained release capsules 300mg [OPUS]
26309 OPTIL XL extra sustained release capsules 240mg [OPUS]
26460 DILCARDIA XL modified release capsules 240mg [GEN (UK)]
26463 ZEMRET XL capsules 240mg [NEOLAB]
26674 verapamil hydrochloride injection 5mg/2ml
26759 ZILDIL SR modified release capsules 60mg [CHANELLE]
27135 DILTIAZEM SR capsules 90mg [HILLCROSS]
27136 DILTIAZEM HYDROCHLORIDE modified release tablet 90mg [HILLCROSS]
27295 SECURON IV injection 5mg/2ml [ABBOTT]
27401 KENZEM SR capsules 90mg [KENT]
27685 DILTIAZEM HYDROCHLORIDE XL capsules 300mg [PLIVA]
28843 VERAPAMIL HYDROCHLORIDE tablets 80mg [CELLTECH]
28844 BERKATENS tablets 120mg [BERK]
28949 BI-CARZEM SR capsules 120mg [TILLOMED]
29637 VERAPRESS MR tablets 240mg [TEVA]
29676 CALAZEM modified release tablet 60mg [BERK]
30197 diltiazem modified release capsules 120mg
30242 diltiazem modified release capsules 180mg
30462 ETHIMIL modified release tablet 240mg [GENUS]
30491 DILTIAZEM HYDROCHLORIDE
31489 BI-CARZEM XL capsules 240mg [TILLOMED]
31490 ZOLVERA oral solution 40mg/5ml [ROSEMONT]
31676 DILTIAZEM HYDROCHLORIDE modified release tablet 120mg [ACTAVIS]
31711 VERAPAMIL HYDROCHLORIDE tablets 80mg [HILLCROSS]
31737 ZILDIL SR modified release capsules 120mg [CHANELLE]
32089 DILTIAZEM HYDROCHLORIDE SR capsules 120mg [HILLCROSS]
32262 DILTIAZEM HYDROCHLORIDE tablets 60mg [CP PHARM]
32590 VERAPAMIL HYDROCHLORIDE tablets 40mg [GEN (UK)]
32658 DILCARDIA XL modified release capsules 120mg [GEN (UK)]
32870 DILTIAZEM HYDROCHLORIDE tablets 60mg [STERWIN]
33471 VERAPAMIL HYDROCHLORIDE tablets 40mg [ACTAVIS]
34377 DILTIAZEM HYDROCHLORIDE SR capsules 90mg [HILLCROSS]
34475 DILTIAZEM HYDROCHLORIDE modified release tablet 90mg [IVAX]
34581 DILTIAZEM HYDROCHLORIDE modified release tablet 60mg [KENT]
34824 DILTIAZEM HYDROCHLORIDE modified release tablet 120mg [IVAX]
34959 VERAPAMIL HYDROCHLORIDE tablets 40mg [HILLCROSS]
35696 KENZEM SR capsules 120mg [KENT]
35729 VERAPAMIL HYDROCHLORIDE tablets 80mg [TEVA]
36583 ZEMRET XL capsules 180mg [NEOLAB]
36664 ZEMRET XL capsules 300mg [NEOLAB]
37774 KENZEM SR capsules 60mg [KENT]
38066 DILTIAZEM HYDROCHLORIDE modified release tablet 60mg [LAGAP]
38545 TILDIEM LA capsules 200mg [SANOFI S]
38632 ADIZEM SR capsules 90mg [NAPPPHARM]
38634 ADIZEM XL capsules 300mg [NAPPPHARM]
38818 ADIZEM SR capsules 120mg [NAPPPHARM]
38831 ADIZEM SR capsules 180mg [NAPPPHARM]
38855 ADIZEM XL capsules 180mg [NAPPPHARM]
38865 ADIZEM XL capsules 120mg [NAPPPHARM]
38876 TILDIEM LA capsules 300mg [SANOFI S]
38882 ADIZEM XL capsules 240mg [NAPPPHARM]
38964 ADIZEM SR tablets 120mg [NAPPPHARM]
39009 VERAPAMIL HYDROCHLORIDE tablets 40mg [TEVA]
39171 BI-CARZEM SR capsules 60mg [TILLOMED]
39298 BI-CARZEM SR capsules 90mg [TILLOMED]
40405 VERAPAMIL HYDROCHLORIDE tablets 120mg [TEVA]
41489 BI-CARZEM SR capsules 120mg [TILLOMED]
41586 VERAPAMIL HYDROCHLORIDE tablets 80mg [ACTAVIS]
41635 DILTIAZEM HYDROCHLORIDE tablets 60mg [IVAX]
41679 VERAPAMIL HYDROCHLORIDE tablets 80mg [IVAX]
41693 VERAPAMIL HYDROCHLORIDE tablets 120mg [GEN (UK)]

Read terms are hierarhically organized in top-level chapters i.e. chapter G....00 is related to Circulatory System Diseases and sub-headings i.e. heading G2...00 is related to Hypertensive Heart Disease while G3...00 is related to Ischaemic Heart Disease.

Secondary Care (incident and prevalent)

In Hospital Episode Statistics (HES, hospital admission data) we used ICD-10 terms (see below) for diagnosis when marked as the primary diagnosis i.e. the main condition treated or investigated during the relevant episode of healthcare. We used the date of admission to hospital as the date of the event. We additionally searched for OPCS-4 terms indicating releted procedures.

Hypertrophic cardiomyopathy diagnoses

ICD-10 codeICD-10 termCALIBER category
I421 Obstructive hypertrophic cardiomyopathy HCM
I422 Other hypertrophic cardiomyopathy HCM
Hypertrophic cardiomyopathy procedures

OPCS-4 codeOPCS-4 termCALIBER category
K24.1 Relief of right ventricular outflow tract obstruction Relief ventricular tract outflow obstruction
K24.5 Relief of left ventricular outflow tract obstruction Relief ventricular tract outflow obstruction
K24.6 Myectomy of left ventricular outflow tract Relief ventricular tract outflow obstruction
K59 Cardioverter defibrillator introduced through the vein Cardioverter defibrillator implantation/renewal
K59.1 Implantation of cardioverter defibrillator using one electrode lead Cardioverter defibrillator implantation/renewal
K59.2 Implantation of cardioverter defibrillator using two electrode leads Cardioverter defibrillator implantation/renewal
K59.3 Resiting of lead of cardioverter defibrillator Cardioverter defibrillator implantation/renewal
K59.4 Renewal of cardioverter defibrillator Cardioverter defibrillator implantation/renewal
K59.6 Implantation of cardioverter defibrillator using three electrode leads Cardioverter defibrillator implantation/renewal
K59.8 Other specified cardioverter defibrillator introduced through the vein Cardioverter defibrillator implantation/renewal
K59.9 Unspecified cardioverter defibrillator introduced through the vein Cardioverter defibrillator implantation/renewal
K59.5 Removal of cardioverter defibrillator Cardioverter defibrillator removal
K60 Cardiac pacemaker system introduced through vein Cardiac pacemaker implantation/renewal
K60.1 Implantation of intravenous cardiac pacemaker system NEC Cardiac pacemaker implantation/renewal
K60.2 Resiting of lead of intravenous cardiac pacemaker system Cardiac pacemaker implantation/renewal
K60.3 Renewal of intravenous cardiac pacemaker system Cardiac pacemaker implantation/renewal
K60.5 Implantation of intravenous single chamber cardiac pacemaker system Cardiac pacemaker implantation/renewal
K60.6 Implantation of intravenous dual chamber cardiac pacemaker system Cardiac pacemaker implantation/renewal
K60.7 Implantation of intravenous biventricular cardiac pacemaker system Cardiac pacemaker implantation/renewal
K60.8 Other specified cardiac pacemaker system introduced through vein Cardiac pacemaker implantation/renewal
K60.9 Unspecified cardiac pacemaker system introduced through vein Cardiac pacemaker implantation/renewal
K61 Other cardiac pacemaker system Cardiac pacemaker implantation/renewal
K61.1 Implantation of cardiac pacemaker system NEC Cardiac pacemaker implantation/renewal
K61.2 Resiting of lead of cardiac pacemaker system NEC Cardiac pacemaker implantation/renewal
K61.3 Renewal of cardiac pacemaker system NEC Cardiac pacemaker implantation/renewal
K61.5 Implantation of single chamber cardiac pacemaker system Cardiac pacemaker implantation/renewal
K61.6 Implantation of dual chamber cardiac pacemaker system Cardiac pacemaker implantation/renewal
K61.7 Implantation of biventricular cardiac pacemaker system Cardiac pacemaker implantation/renewal
K61.8 Other specified other cardiac pacemaker system Cardiac pacemaker implantation/renewal
K61.9 Unspecified other cardiac pacemaker system Cardiac pacemaker implantation/renewal
K60.4 Removal of intravenous cardiac pacemaker system Cardiac pacemaker removal
K61.4 Removal of cardiac pacemaker system NEC Cardiac pacemaker removal
U31 Pacemaker testing Cardiac pacemaker removal
U31.1 Distant pacemaker test Cardiac pacemaker testing
U31.8 Other specified pacemaker testing Cardiac pacemaker testing
U31.9 Unspecified pacemaker testing Cardiac pacemaker testing
K62 Therapeutic transluminal operations on heart Conductive heart system ablation
K62.1 Percutaneous transluminal ablation of pulmonary vein to left atrium conducting system Conductive heart system ablation
K62.2 Percutaneous transluminal ablation of atrial wall for atrial flutter Conductive heart system ablation
K62.3 Percutaneous transluminal ablation of conducting system of heart for atrial flutter NEC Conductive heart system ablation
K62.4 Percutaneous transluminal internal cardioversion NEC Internal cardioversion
Not applicable.

Combining evidence across sources to define and date phenotypes

CALIBER Atrial Fibrillation Phenotype flowchart
Flow chart diagram illustrating the CALIBER phenotype algorithm for atrial fibrillation
Risk factor Publication
HCM Pujades-Rodriguez, Mar, Oliver P. Guttmann, Arturo Gonzalez-Izquierdo, Bram Duyx, Constantinos O’Mahony, Perry Elliott, and Harry Hemingway. "Identifying unmet clinical need in hypertrophic cardiomyopathy using national electronic health records." PloS one 13, no. 1 (2018): e0191214.
Pujades-Rodriguez, Mar, Oliver P. Guttmann, Arturo Gonzalez-Izquierdo, Bram Duyx, Constantinos O’Mahony, Perry Elliott, and Harry Hemingway. "Identifying unmet clinical need in hypertrophic cardiomyopathy using national electronic health records." PloS one 13, no. 1 (2018): e0191214.