CALIBER HIV infection phenotype

person Phenotype HIV infection
person Type Categorical, disease or syndrome
person Data sources Primary care (CPRD), hospital admission data (HES)
person Clinical Terminologies Read, ICD-10, ICD-9, OPCS-4
person Valid event date range 01/01/1999 - 01/07/2016
person Sex Female/Male
person Agreed 23.11.2012 (Revision 2)
person Authors Daskalopoulou M, Phillips AN, Gonzalez-Izquierdo A, Smeeth L, Denaxas S

Primary Care (incident)

In the Clinical Practice Research Datalink (CPRD, primary care data) we ascertained deoression cases by searching for Read terms related to a diagnosis.


Read codeRead termCALIBER category
43C3.11 HIV positive HIV+
65QA.00 AIDS carrier HIV+
A788.11 Human immunodeficiency virus infection HIV+
A788000 Acute human immunodeficiency virus infection HIV+
A788100 Asymptomatic human immunodeficiency virus infection HIV+
A788200 HIV infection with persistent generalised lymphadenopathy HIV+
A788300 Human immunodeficiency virus with constitutional disease HIV+
A788400 Human immunodeficiency virus with neurological disease HIV+
A788500 Human immunodeficiency virus with secondary infection HIV+
A788U00 HIV disease result/haematological+immunologic abnorms,NEC HIV+
A788W00 HIV disease resulting in unspecified malignant neoplasm HIV+
A788X00 HIV disease resulting/unspcf infectious+parasitic disease HIV+
A788y00 Human immunodeficiency virus with other clinical findings HIV+
A788z00 Acquired human immunodeficiency virus infection syndrome NOS HIV+
A789.00 Human immunodef virus resulting in other disease HIV+
A789000 HIV disease resulting in mycobacterial infection HIV+
A789100 HIV disease resulting in cytomegaloviral disease HIV+
A789200 HIV disease resulting in candidiasis HIV+
A789400 HIV disease resulting in multiple infections HIV+
A789700 HIV dis resulting oth types of non-Hodgkin's lymphoma HIV+
A789900 HIV disease resulting in lymphoid interstitial pneumonitis HIV+
A789X00 HIV dis reslt/oth mal neopl/lymph,h'matopoetc+reltd tissu HIV+
AyuC.00 [X]Human immunodeficiency virus disease HIV+
AyuC600 [X]HIV disease resulting in other non-Hodgkin's lymphoma HIV+
AyuCB00 [X]HIV disease result/haematological+immunologic abnorms,NEC HIV+
Eu02400 [X]Dementia in human immunodef virus [HIV] disease HIV+
R109.00 [D]Laboratory evidence of human immunodeficiency virus [HIV] HIV+
ZV01A00 [V]Asymptomatic human immunodeficency virus infection status HIV+
A788.00 Acquired immune deficiency syndrome AIDS
A789300 HIV disease resulting in Pneumocystis carinii pneumonia AIDS
A789500 HIV disease resulting in Kaposi's sarcoma AIDS
A789600 HIV disease resulting in Burkitt's lymphoma AIDS
A789A00 HIV disease resulting in wasting syndrome AIDS

Primary Care (HIV negative)


Read codeRead termCALIBER category
43C2.11 HIV negative HIV-
ZV01800 [V]Human immunodeficiency virus - negative HIV-
Read terms are hierarhically organized in top-level chapters i.e. chapter G....00 is related to Circulatory System Diseases and sub-headings i.e. heading G2...00 is related to Hypertensive Heart Disease while G3...00 is related to Ischaemic Heart Disease.

Secondary Care (incident and prevalent)

In Hospital Episode Statistics (HES, hospital admission data) we used ICD-10 terms (see below) for diagnosis when marked as the primary diagnosis i.e. the main condition treated or investigated during the relevant episode of healthcare. We used the date of admission to hospital as the date of the event.


ICD-10 codeICD-10 termCALIBER category
B200 HIV disease resulting in mycobacterial infection HIV+
B201 HIV disease resulting in other bacterial infections HIV+
B202 HIV disease resulting in cytomegaloviral disease HIV+
B203 HIV disease resulting in other viral infections HIV+
B204 HIV disease resulting in candidiasis HIV+
B205 HIV disease resulting in other mycoses HIV+
B207 HIV disease resulting in multiple infections HIV+
B208 HIV disease resulting in other infectious and parasitic diseases HIV+
B209 HIV disease resulting in unspecified infectious or parasitic disease HIV+
B212 HIV disease resulting in other types of non-Hodgkin lymphoma HIV+
B213 HIV disease resulting in other malignant neoplasms of lymphoid, haematopoietic and related tissue HIV+
B217 HIV disease resulting in multiple malignant neoplasms HIV+
B218 HIV disease resulting in other malignant neoplasms HIV+
B219 HIV disease resulting in unspecified malignant neoplasm HIV+
B221 HIV disease resulting in lymphoid interstitial pneumonitis HIV+
B227 HIV disease resulting in multiple diseases classified elsewhere HIV+
B23 Human immunodeficiency virus [HIV] disease resulting in other conditions HIV+
B24 Unspecified human immunodeficiency virus [HIV] disease HIV+
F024 Dementia in human immunodeficiency virus [HIV] disease HIV+
R75 Laboratory evidence of human immunodeficiency virus [HIV] HIV+
Z21 Asymptomatic human immunodeficiency virus [HIV] infection status HIV+
B206 HIV disease resulting in Pneumocystis jirovecii pneumonia AIDS
B210 HIV disease resulting in Kaposi sarcoma AIDS
B211 HIV disease resulting in Burkitt lymphoma AIDS
B220 HIV disease resulting in encephalopathy AIDS
B222 HIV disease resulting in wasting syndrome AIDS
_
Not applicable.

Combining evidence across sources to define and date phenotypes

Risk factor Publication
HIV Daskalopoulou, M., A. Phillips, A. Gonzalez-Izquierdo, L. Smeeth, and S. Denaxas. "HIV as a risk factor in the initial presentation of a range of cardiovascular, coronary, cerebrovascular, and peripheral arterial diseases: a linked electronic health records study of 8 million adults in the UK." In HIV MEDICINE, vol. 19, pp. S78-S79. 111 RIVER ST, HOBOKEN 07030-5774, NJ USA: WILEY, 2018.
Daskalopoulou, M., A. Phillips, A. Gonzalez-Izquierdo, L. Smeeth, and S. Denaxas. "HIV as a risk factor in the initial presentation of a range of cardiovascular, coronary, cerebrovascular, and peripheral arterial diseases: a linked electronic health records study of 8 million adults in the UK." In HIV MEDICINE, vol. 19, pp. S78-S79. 111 RIVER ST, HOBOKEN 07030-5774, NJ USA: WILEY, 2018.