CALIBER Giant cell arteritis phenotype

person Phenotype Giant cell arteritis
person Type Disease or syndrome
person Data sources Primary care (CPRD), hospital admission data (HES)
person Clinical Terminologies Read, ICD-9, ICD-10
person Valid event date range 01/01/1999 - 01/07/2016
person Sex Female/Male
person Agreed 23.11.2012 (Revision 2)
person Authors Mar Pujades-Rodriguez , Bram Duyx, Sara L. Thomas, Dimitris Stogiannis, Anisur Rahman, Liam Smeeth, Harry Hemingway

Primary Care (incident and prevalent)

In the Clinical Practice Research Datalink (CPRD, primary care data) we ascertained cases by searching for Read terms related to:

Diagnoses

Read codeRead termCALIBER category
G755100 Temporal arteritis Giant cells
G755000 Cranial arteritis Giant cells
G755.00 Giant cell arteritis Giant cells
N200.00 Giant cell arteritis with polymyalgia rheumatica Giant cells
Nyu4100 [X]Other giant cell arteritis Giant cells
G755z00 Giant cell arteritis NOS Giant cells
G52y111 Giant cell myocarditis Giant cells
Disease-modifying antirheumatic drugs (DMARD)

Product codeMedication
38056 ciclosporin concentrate for solution for infusion 50mg/1ml
39111 rituximab concentrate for intravenous infusion 10mg/ml
39115 azathioprine capsules 10mg
40273 methotrexate injection 20mg/0.4ml
40280 METOJECT injection 7.5mg/0.15ml [MEDAC UK]
40281 methotrexate injection 15mg/0.3ml
40284 METOJECT injection 15mg/0.3ml [MEDAC UK]
40292 METOJECT injection 20mg/0.4ml [MEDAC UK]
40293 METOJECT injection 25mg/0.5ml [MEDAC UK]
40301 methotrexate injection 7.5mg/0.15ml
40328 methotrexate injection 25mg/0.5ml
40356 METOJECT injection 10mg/0.2ml [MEDAC UK]
40371 methotrexate injection 10mg/0.2ml
41086 methotrexate injection 5000mg/50ml
41104 METHOTREXATE tablets 2.5mg [CP PHARM]
41585 METHOTREXATE SODIUM tablets 2.5mg [WYETH PHAR]
41620 AZATHIOPRINE tablets 50mg [TEVA]
41670 AZATHIOPRINE tablets 50mg [CP PHARM]

Read terms are hierarhically organized in top-level chapters i.e. chapter G....00 is related to Circulatory System Diseases and sub-headings i.e. heading G2...00 is related to Hypertensive Heart Disease while G3...00 is related to Ischaemic Heart Disease.

Secondary Care (incident and prevalent)

In Hospital Episode Statistics (HES, hospital admission data) we used ICD-10 terms (see below) for diagnosis when marked as the primary diagnosis i.e. the main condition treated or investigated during the relevant episode of healthcare. We used the date of admission to hospital as the date of the event. We additionally searched for OPCS-4 terms indicating releted procedures.

Diagnoses

ICD-10 codeICD-10 termCALIBER category
M316 Other giant cell arteritis Giant cells
Not applicable.
Pujades-Rodriguez M et al. Associations between polymyalgia rheumatica and giant cell arteritis and 12 cardiovascular diseases. Heart. 2016 Mar;102(5):383-9. doi: 10.1136/heartjnl-2015-308514. Epub 2016 Jan 19. PMID: 26786818