CALIBER Bullous disorder phenotype

person Phenotype Bullous disorder
person Type Disease or syndrome
person Data sources Primary care (CPRD), hospital admission data (HES)
person Clinical Terminologies Read, ICD-9, ICD-10
person Valid event date range 01/01/1999 - 01/07/2016
person Sex Female/Male
person Agreed 23.11.2012 (Revision 2)
person Authors Mar Pujades-Rodriguez , Bram Duyx, Sara L. Thomas, Dimitris Stogiannis, Anisur Rahman, Liam Smeeth, Harry Hemingway

Primary Care (incident and prevalent)

In the Clinical Practice Research Datalink (CPRD, primary care data) we ascertained cases by searching for Read terms related to:

Diagnoses

Read codeRead termCALIBER category
M145.00 Pemphigoid Bullous
M140.00 Dermatitis herpetiformis Bullous
M145000 Bullous pemphigoid Bullous
M144.00 Pemphigus Bullous
M145100 Benign pemphigus NOS Bullous
M170300 Lichen planus bullosus Bullous
M141.00 Subcorneal pustular dermatosis Bullous
M144600 Pemphigus vulgaris Bullous
M144300 Foliaceous pemphigus Bullous
M145200 Senile dermatitis herpetiformis Bullous
M146.00 Benign mucous membrane pemphigoid Bullous
F4Cy100 Ocular pemphigoid Bullous
M146011 Cicatricial pemphigoid Bullous
M146100 Ocular pemphigoid Bullous
M144200 Erythematous pemphigus Bullous
M144000 Benign pemphigus Bullous
M144z00 Pemphigus NOS Bullous
M144500 Pemphigus vegetans Bullous
M146z00 Benign mucous membrane pemphigoid NOS Bullous
M145z00 Pemphigoid NOS Bullous
M144700 Wildfire pemphigus Bullous
M140.11 Duhring's disease Bullous
Myu1200 [X]Other pemphigoid Bullous
M146000 Benign mucous membrane pemphigoid with no eye involvement Bullous
Myu1000 [X]Other pemphigus Bullous
Disease-modifying antirheumatic drugs (DMARD)

Product codeMedication
77 oxytetracycline tablets 250mg
121 tetracycline capsules 250mg
132 oxytetracycline capsules 250mg
293 chlortetracycline ophthalmic ointment 1%
311 DERMOVATE cream 0.05% [GLAXO]
386 tetracycline tablets 250mg
738 chlortetracycline with demeclocycline and tetracycline tablets
777 DERMOVATE -NN cream [GLAXO]
799 tetracycline eye drops 1%
806 tetracycline topical solution 2.2mg/ml
823 methotrexate tablets 2.5mg
839 IMMUNOGLOBULIN 250 I/U INJ
877 methotrexate tablets 10mg
1013 MYSTECLIN capsules [BMS]
1023 DERMOVATE ointment 0.05% [GLAXO]
1141 immunoglobulin human normal IM injection 16%
1326 TERRA-CORTRIL ointment [PFIZER]
1328 GAMMABULIN IM injection 16% [HYLAND]
1340 PROPADERM -A ointment [GLAXO]
1389 TRIMOVATE cream [GLAXO]
1457 TERRA-CORTRIL NYSTATIN cream [PFIZER]
1479 ACHROMYCIN eye ointment 1% [WYETH PHAR]
1578 AUREOMYCIN ophthalmic ointment 1% [WYETH PHAR]
1606 AUREOCORT cream [WYETH PHAR]
1607 AUREOCORT ointment [WYETH PHAR]
1682 clobetasol propionate cream 0.05%
1828 MYSTECLIN tablets [BMS]
1881 TRIMOVATE ointment [GLAXO]
1916 NICOTINAMIDE 25 MG TAB
1955 DERMOVATE -NN ointment [GLAXO]
2127 AUREOMYCIN capsules 250mg [WYETH PHAR]
2212 DERMOVATE scalp application 0.05% [GLAXO]
2230 immunoglobulin human normal solution for infusion 50mg/ml
2233 TOPICYCLINE solution [SHIRE]
2256 DETECLO tablets 300mg [WYETH PHAR]
2266 oxytetracycline with hydrocortisone ointment
2458 OXYTETRACYCLINE 100 MG TAB
2636 TETRACYCLINE 500 MG CAP
2813 chlortetracycline cream 3%
2820 KABIGLOBULIN injection 16% [PHARMACIA]
2922 tetracycline with nystatin tablets 250mg + 250,000 units
2983 clobetasol propionate ointment 0.05%
3025 OXYTETRACYCLINE 500 MG TAB
3079 dapsone tablets 50mg
3211 tetracycline eye ointment 1%
3527 ACHROMYCIN ointment 3% [WYETH PHAR]
3528 TETRACYCLINE 500 MG TAB
3542 TERRA-CORTRIL ear suspension [PFIZER]
3816 TETRACHEL tablets 250mg [BERK]
3837 tetracycline ointment 3%
3883 nicotinamide tablets 50mg
3918 AZATHIOPRINE 10 MG TAB
4167 NICOTINAMIDE 100 MG TAB
4202 immunoglobulin human normal injection 250mg/vial
4208 nicotinamide topical gel 4%
4230 mycophenolate mofetil tablets 500mg
4438 mycophenolate mofetil capsules 250mg
4567 AUREOMYCIN cream 3% [WYETH PHAR]
4579 ACHROMYCIN capsules 250mg [WYETH PHAR]
4656 clobetasone butyrate with oxytetracycline and nystatin cream
4940 nystatin with clobetasol propionate and neomycin cream
5876 clobetasol propionate scalp application 0.05%
6201 NICAM topical gel 4% [DERMAL]
6342 AUREOCORT ointment [GOLDSHIELD]
6994 dapsone tablets 100mg
7077 mycophenolate mofetil powder for concentrate for solution for infusion 500mg
7187 triamcinolone acetonide with chlortetracycline hydrochloride ointment 0.1% + 3%
7336 methotrexate injection 12.5mg/0.5ml
7337 methotrexate injection 10mg/0.4ml
7455 TERRAMYCIN capsules 250mg [PFIZER]
7596 chlortetracycline ointment 3%
7637 clobetasol propionate with neomycin ointment
7679 AUREOMYCIN ointment 3% [WYETH PHAR]
7881 chlortetracycline capsules 250mg
8219 TETRACHEL capsules 250mg [BERK]
8231 clobetasol propionate with neomycin cream
8284 tetracycline syrup 125mg/5ml
8285 OXYTETRACYCLINE 250 MG SYR
8327 methotrexate injection 50mg/3ml
8393 NOVOBIOCIN/TETRACYCLINE 125 MG CAP
8583 methotrexate injection 25mg/ml
8776 AZATHIOPRINE 100 MG TAB
8791 immunoglobulin human normal IV injection
9014 TETRABID-ORGANON capsules 250mg [ORGANON]
9034 oxytetracycline syrup 125mg/5ml
9213 CHLORTETRACYCLINE /CLORETASONE BUTYRATE 3 % OIN
9244 nystatin with clobetasol propionate and neomycin ointment
9361 OXYMYCIN tablets 250mg [DDSA]
9528 methotrexate injection 5mg/2ml
10391 TERRA-CORTRIL spray [PFIZER]
10542 OXYTETRACYCLINE HCL/HYDROCORTISONE .5 % EAR
10620 DAPSONE 25 MG TAB
10920 PAPULEX topical gel 4% [STEVENDEN]
10972 oxytetracycline with hydrocortisone spray
12016 CHYMOCYCLAR capsules [RORER]
12220 OXYTETRACYCLINE 3 % OIN
12541 IMPERACIN tablets 250mg [ASTRAZENEC]
12816 methotrexate injection 100mg/ml
12904 oxytetracycline with hydrocortisone and nystatin cream
13286 clobetasol propionate foam 500 micrograms/g
13327 DETECLO tablets 300mg [GOLDSHIELD]
13428 MAXTREX tablets 2.5mg [PHARMACIA]
14347 methotrexate injection 20mg/0.8ml
14348 METOJECT injection 20mg/2ml [MEDAC UK]
14748 methotrexate sodium injection 25mg/ml
15116 immunoglobulin human normal powder for solution for infusion 0.5g
15355 tetracycline with chlortetracycline and demeclocycline tablets
15407 ACHROMYCIN V capsules 250mg [WYETH PHAR]
15508 DAPSONE 75 MG TAB
15513 ACHROMYCIN tablets 250mg [WYETH PHAR]
15556 AZATHIOPRINE 125 MG TAB
15609 SANDOGLOBULIN infusion [NOV/SANDOZ]
15610 SANDOGLOBULIN inf 6 GM INJ
15840 SANDOGLOBULIN infusion 3g [ZLB]
15841 SANDOGLOBULIN infusion 6g [ZLB]
15883 SANDOGLOBULIN infusion 1g [ZLB]
16069 SANDOGLOBULIN NF solution for infusion 6g/50ml [CSL BEHR]
16074 SANDOGLOBULIN infusion 12g [ZLB]
16093 SANDOGLOBULIN NF solution for infusion 12g/100ml [CSL BEHR]
16132 FREEDERM TREATMENT gel [DENDRON]
16519 methotrexate injection 25mg/1ml
16540 methotrexate injection 15mg/0.6ml
16570 methotrexate injection 7.5mg/0.3ml
16879 mycophenolate mofetil oral suspension 1g/5ml
16919 CELLCEPT capsules 250mg [ROCHE]
17035 methotrexate suspension 2.5mg/5ml
17093 BISOLVOMYCIN capsules [BOEH INGL]
17097 DAPSONE 5 MG TAB
17206 AZATHIOPRINE 50 MG SUS
17209 OXYTETRACYCLINE 250 MG INJ
17222 MYSTECLIN syrup [BMS]
17226 ECONOMYCIN capsules 250mg [DDSA]
17284 CHLORTETRACYCLINE HYD./DEMECLOCYCLINE HY 115.4 MG TAB
17337 ALPHAGLOBIN infusion 10g/vial [GRIFOLS]
17347 ALPHAGLOBIN infusion 5g/vial [GRIFOLS]
17467 TERRAMYCIN tablets 250mg [PFIZER]
17672 methotrexate injection 22.5mg/0.9ml
17685 VIGAM LIQUID infusion 50mg/ml [BPL]
17703 OXYTETRAMIX tablets 250mg [ASHBOURNE]
17895 ANTI-D (RHO) IMMUNOGLOBULIN 50 MCG INJ
18326 immunoglobulin human normal powder for solution for infusion 10g
18424 methotrexate sodium tablets 2.5mg
18685 ACHROMYCIN syrup 125mg/5ml [WYETH PHAR]
18723 immunoglobulin human normal powder for solution for infusion 5g
18804 CELLCEPT tablets 500mg [ROCHE]
18890 methotrexate injection 17.5mg/0.7ml
19005 OXYTETRACYCLINE/POLYMYXIN OINT EYE
19314 NICOTINAMIDE 500 MG TAB
19693 SUSTAMYCIN capsules 250mg [BOEH MANN]
19905 beclometasone with chlortetracycline hydrochloride ointment
20377 NICOTINAMIDE 250 MG CAP
20951 METHOTREXATE tablets 2.5mg [GOLDSHIELD]
21366 tetracycline IV injection 250mg/vial
21580 CLARELUX foam 500 micrograms/g [FABRE]
21629 TETRACYCLINE EYE
21654 TETRACYCLINE EAR/EYE
21732 CELLCEPT oral suspension 1g/5ml [ROCHE]
21753 MAXTREX tablets 10mg [PHARMACIA]
21755 triamcinolone acetonide with chlortetracycline hydrochloride cream
21802 BERKMYCEN tablets 250mg [BERK]
21804 tetracycline syrup 125mg/5ml
21889 METHOTREXATE 25MG/1ML
22341 hydrocortisone with oxytetracycline ointment
23502 GAMIMUNE -N IV injection 5g/100ml [???]
23503 GAMIMUNE -N IV injection 500mg/vial [???]
23504 ALPHAGLOBIN infusion 2.5g/vial [GRIFOLS]
23527 FLEBOGAMMA infusion 50mg/ml [GRIFOLS]
23585 FLEBOGAMMA infusion 10g/vial [GRIFOLS]
23739 immunoglobulin human normal subcutaneous infusion/intramuscular injection 16%
23857 DAPSONE 12.5 MG TAB
24059 GAMMAGARD infusion 10g [BAXTER]
24487 ANTI-D (RHo) IMMUNOGLOBULIN
24634 methotrexate injection 25mg/2.5ml
24643 demeclocycline with chlortetracycline and tetracycline tablets
24644 VIGAM S powder for solution for infusion 5g [BPL]
24783 methotrexate injection 50mg/2ml
25017 TETRACYCLINE
25071 tetracycline with nystatin capsules
25201 SUBCUVIA subcutaneous infusion/intramuscular injection 16% [BAXTER]
25274 tetracycline IV injection 500mg/vial
25752 nystatin with tetracycline hydrochloride capsules
25807 immunoglobulin human normal injection 750mg/vial
26064 methotrexate injection 20mg/2ml
26111 ECONOMYCIN tablets 250mg [DDSA]
26505 DAPSONE 200 MG TAB
26876 GAMIMUNE -N IV injection 2.5g/vial [???]
27342 MAXTREX injection 2.5mg/ml [PHARMACIA]
27400 METOJECT injection 15mg/1.5ml [MEDAC UK]
27404 methotrexate injection 15mg/1.5ml
27421 NICOTINAMIDE (B3) 500 MG TAB
27473 CHLORTETRACYCLINE HYDROCHLORIDE EYE
27503 immunoglobulin human normal powder for solution for infusion 2.5g
27579 METHOTREXATE
27642 methotrexate injection 27.5mg/1.1ml
28041 methotrexate oral suspension 12.5mg/5ml
28291 OXYTETRACYCLINE 3%/HYDROCORTISONE 1%
28334 immunoglobulin human normal powder for solution for infusion 6g
28489 immunoglobulin human normal powder for solution for infusion 1g
28490 rituximab concentrate for solution for infusion 100mg/10ml
28573 ACHROMYCIN IM injection 100mg/vial [WYETH PHAR]
28736 TETRACYCLINE HYDROCHLORIDE/AMPHOTERICIN SYR
29069 methotrexate sterile powder 500mg/vial
29308 immunoglobulin human normal solution for infusion 6g/50ml
29340 AZATHIOPRINE tablets 50mg [IVAX]
30581 CELLCEPT powder for concentrate for solution for infusion 500mg [ROCHE]
30604 hydrocortisone with nystatin and oxytetracycline cream
30703 methotrexate injection 30mg/1.2ml
30780 METHOTREXATE tablets 2.5mg [PHARMACIA]
30932 methotrexate injection 5mg/0.2ml
31007 AUREOMYCIN powder [WYETH PHAR]
31215 AZATHIOPRINE tablets 50mg [KENT]
31230 ACHROMYCIN IV injection 500mg/vial [WYETH PHAR]
31425 TETRACYCLINE HCL/PANCREATIC CONCENTRATE CAP
31443 immunoglobulin human normal solution for infusion 10g/200ml
31476 ACHROMYCIN IV injection 250mg/vial [WYETH PHAR]
32101 AZATHIOPRINE tablets 25mg [HILLCROSS]
32111 METHOTREXATE tablets 2.5mg [MAYNE]
32229 methotrexate injection 500mg/20ml
32233 ACHROMYCIN powder [WYETH PHAR]
32274 SUBGAM injection 750mg/vial [BPL]
32865 methotrexate injection 10mg/1ml
32998 immunoglobulin human normal solution for infusion 12g/100ml
33601 METOJECT injection 25mg/2.5ml [MEDAC UK]
34011 tetracycline capsules 250mg
34032 DAPSONE tablets 100mg [ACTAVIS]
34040 OXYTETRACYCLINE tablets 250mg [ACTAVIS]
34044 OXYTETRACYCLINE tablets 250mg [HILLCROSS]
34056 IMMUNOGLOBULIN HUMAN NORMAL IM injection 250mg [BPL]
34141 OXYTETRACYCLINE tablets 250mg [APS]
34258 METHOTREXATE injection 20mg/0.8ml [CENT HOME]
34336 OXYTETRACYCLINE tablets 250mg [IVAX]
34451 AZATHIOPRINE tablets 50mg [GEN (UK)]
34687 AZATHIOPRINE tablets 50mg [HILLCROSS]
34816 AZATHIOPRINE tablets 25mg [GEN (UK)]
34888 OXYTETRACYCLINE tablets 250mg [CP PHARM]
34929 METHOTREXATE tablets 10mg [MAYNE]
35402 methotrexate injection 7.5mg/0.75ml
35752 methotrexate oral suspension 7.5mg/5ml
35865 METOJECT injection 7.5mg/0.75ml [MEDAC UK]
35891 FLEBOGAMMA infusion 10g/200ml [GRIFOLS]
35892 FLEBOGAMMA infusion 5g/100ml [GRIFOLS]
36014 ETRIVEX shampoo 500 micrograms/g [GALDERMA]
36034 immunoglobulin human normal solution for infusion 5g/100ml
36123 OCTAGAM infusion 10g/200ml [OCTAPHARMA]
36124 OCTAGAM infusion 5g/100ml [OCTAPHARMA]
36167 methotrexate injection 1000mg/10ml
36226 clobetasol propionate shampoo 500 micrograms/g
36294 rituximab concentrate for solution for infusion 500mg/50ml
36451 OCTAGAM infusion 50mg/ml [OCTAPHARMA]
36689 CHLORTETRACYCLINE HCl SYR
36800 methotrexate oral solution 10mg/5ml
36849 methotrexate oral suspension 10mg/5ml
37117 METOJECT injection 10mg/1ml [MEDAC UK]
37683 GAMMAGARD infusion 0.5g [BAXTER]
38074 chlortetracycline with hydrocortisone cream
38118 ACHROMYCIN ear ointment 1% [WYETH PHAR]
39111 rituximab concentrate for intravenous infusion 10mg/ml
39586 immunoglobulin human normal solution for infusion 2.5g/50ml
39587 FLEBOGAMMA infusion 2.5g/50ml [GRIFOLS]
39926 PRIVIGEN solution for infusion 5g/50ml [CSL BEHR]
39927 PRIVIGEN solution for infusion 10g/100ml [CSL BEHR]
40273 methotrexate injection 20mg/0.4ml
40280 METOJECT injection 7.5mg/0.15ml [MEDAC UK]
40281 methotrexate injection 15mg/0.3ml
40284 METOJECT injection 15mg/0.3ml [MEDAC UK]
40285 FREEDERM gel [DENDRON]
40292 METOJECT injection 20mg/0.4ml [MEDAC UK]
40293 METOJECT injection 25mg/0.5ml [MEDAC UK]
40301 methotrexate injection 7.5mg/0.15ml
40328 methotrexate injection 25mg/0.5ml
40356 METOJECT injection 10mg/0.2ml [MEDAC UK]
40371 methotrexate injection 10mg/0.2ml
40483 OXYTETRACYCLINE tablets 250mg [SANDOZ]
40583 DERMOVATE -NN cream [CHEMIDEX]
40698 DERMOVATE -NN ointment [CHEMIDEX]
40953 FLEBOGAMMA infusion 500mg/10ml [GRIFOLS]
41086 methotrexate injection 5000mg/50ml
41104 METHOTREXATE tablets 2.5mg [CP PHARM]
41268 VIGAM LIQUID infusion 2.5g/50ml [BPL]
41388 clobetasol propionate ointment with coal tar solution in white soft paraffin (bcm) ointment 25% + 5%
41457 immunoglobulin human normal solution for infusion 500mg/10ml
41547 TETRACYCLINE capsules 250mg [BERK]
41585 METHOTREXATE SODIUM tablets 2.5mg [WYETH PHAR]
41620 AZATHIOPRINE tablets 50mg [TEVA]
41636 TETRACYCLINE tablets 250mg [ACTAVIS]
41670 AZATHIOPRINE tablets 50mg [CP PHARM]

Read terms are hierarhically organized in top-level chapters i.e. chapter G....00 is related to Circulatory System Diseases and sub-headings i.e. heading G2...00 is related to Hypertensive Heart Disease while G3...00 is related to Ischaemic Heart Disease.

Secondary Care (incident and prevalent)

In Hospital Episode Statistics (HES, hospital admission data) we used ICD-10 terms (see below) for diagnosis when marked as the primary diagnosis i.e. the main condition treated or investigated during the relevant episode of healthcare. We used the date of admission to hospital as the date of the event. We additionally searched for OPCS-4 terms indicating releted procedures.

Diagnoses

ICD-10 codeICD-10 termCALIBER category
H201 Chronic iridocyclitis Uveitis
H208 Other iridocyclitis Uveitis
H209 Iridocyclitis, unspecified Uveitis
H221 Iridocyclitis in other diseases classified elsewhere - ank spond/sarcoid Uveitis
H301 Disseminated chorioretinal inflammation Uveitis
H302 Posterior cyclitis (Pars Planitis) Uveitis
Not applicable.

Combining evidence across sources to define and date phenotypes

CALIBER bullous disorders Phenotype flowchart
Flow chart diagram illustrating the CALIBER phenotype algorithm for bullous disorders
Pujades-Rodriguez, Mar, Bram Duyx, Sara L. Thomas, Dimitris Stogiannis, Anisur Rahman, Liam Smeeth, and Harry Hemingway. "Rheumatoid arthritis and incidence of twelve initial presentations of cardiovascular disease: a population record-linkage cohort study in England." PLoS One 11, no. 3 (2016): e0151245.